Okawa T, Kita M, Tanaka M, Ikeda M
Department of Radiology, Tokyo Women's Medical College, Japan.
Int J Radiat Oncol Biol Phys. 1989 Jul;17(1):49-54. doi: 10.1016/0360-3016(89)90369-6.
Three hundred and eleven patients with locally advanced esophageal cancer were treated by radiation therapy from 1968 to 1983 at Tokyo Women's Medical College. Of these, 288 patients with previously untreated, histologically confirmed squamous cell carcinoma but previously treated with curative intent, were eligible for analysis. The cumulative 5-year survival rate of 288 patients given radical radiotherapy was 9.0%. Sex, tumor length, and Stage (AJC) had a great influence on prognosis. The five-year survival rate in males was 5.4% and in females was 22.4%. The five-year survival rate in cases with a tumor length of 5 cm or less was 17.7% in 5-10 cm was 10.0%, and in 10 cm or above was 2.8% and they were 20.2% for Stage I, 9.9% for Stage II, and 2.6% for Stage III. There were no significant differences of survival rate among age, tumor site, and tumor type on X ray film. This data suggests that comparatively early, small-volume tumors share a significant potential for cure by radiotherapy, but potent combined therapy is necessary for the treatment of advanced cancers.
1968年至1983年期间，东京女子医科大学对311例局部晚期食管癌患者进行了放射治疗。其中，288例患者此前未经治疗，但经组织学确诊为鳞状细胞癌且曾接受过根治性治疗，符合分析条件。接受根治性放疗的288例患者的5年累积生存率为9.0%。性别、肿瘤长度和分期（AJC）对预后有很大影响。男性的5年生存率为5.4%，女性为22.4%。肿瘤长度在5厘米及以下的患者5年生存率为17.7%，5至10厘米的为10.0%，10厘米及以上的为2.8%；I期患者为20.2%，II期为9.9%，III期为2.6%。年龄、肿瘤部位和X线片上的肿瘤类型之间的生存率无显著差异。该数据表明，相对早期、小体积的肿瘤通过放疗有显著的治愈潜力，但晚期癌症的治疗需要有效的联合治疗。
