Department of Diagnostic Radiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Department of Technology, Faculty of Health and Technology, Metropolitan University College, DK-2100 Copenhagen, Denmark.
Diagnostics (Basel). 2016 Sep 6;6(3):34. doi: 10.3390/diagnostics6030034.
The aim of this systematic review is to provide an overview of the use of Dynamic Contrast-enhanced Computed Tomography (DCE-CT) in patients with pancreatic cancer. This study was composed according to the PRISMA guidelines 2009. The literature search was conducted in PubMed, Cochrane Library, EMBASE, and Web of Science databases to identify all relevant publications. The QUADAS-2 tool was implemented to assess the risk of bias and applicability concerns of each included study. The initial literature search yielded 483 publications. Thirteen articles were included. Articles were categorized into three groups: nine articles concerning primary diagnosis or staging, one article about tumor response to treatment, and three articles regarding scan techniques. In exocrine pancreatic tumors, measurements of blood flow in eight studies and blood volume in seven studies were significantly lower in tumor tissue, compared with measurements in pancreatic tissue outside of tumor, or normal pancreatic tissue in control groups of healthy volunteers. The studies were heterogeneous in the number of patients enrolled and scan protocols. Perfusion parameters measured and analyzed by DCE-CT might be useful in the investigation of characteristic vascular patterns of exocrine pancreatic tumors. Further clinical studies are desired for investigating the potential of DCE-CT in pancreatic tumors.
本系统评价的目的是提供一个使用动态对比增强计算机断层扫描（DCE-CT）在胰腺癌患者的概述。本研究根据 PRISMA 指南 2009 进行。文献检索在 PubMed、Cochrane 图书馆、EMBASE 和 Web of Science 数据库中进行，以确定所有相关的出版物。采用 QUADAS-2 工具评估每个纳入研究的偏倚风险和适用性问题。最初的文献检索产生了 483 篇出版物。有 13 篇文章被纳入。文章分为三组：9 篇关于原发性诊断或分期，1 篇关于肿瘤对治疗的反应，以及 3 篇关于扫描技术。在外分泌胰腺肿瘤中，与肿瘤外胰腺组织或健康志愿者对照组的正常胰腺组织相比，八项研究中肿瘤组织的血流测量值和七项研究中血容量测量值均显著降低。研究在入组患者数量和扫描方案上存在异质性。DCE-CT 测量和分析的灌注参数可能有助于研究外分泌胰腺肿瘤的特征性血管模式。需要进一步的临床研究来研究 DCE-CT 在胰腺肿瘤中的潜力。
