Rezende Rosamar E F, Duarte Sebastião M B, Stefano Jose T, Roschel Hamilton, Gualano Bruno, de Sá Pinto Ana L, Vezozzo Denise C P, Carrilho Flair J, Oliveira Claudia P
1Department of Gastroenteology2Division of Rheumatology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Menopause. 2016 Aug;23(8):876-83. doi: 10.1097/GME.0000000000000647.
The aim of the study was to evaluate the effectiveness of aerobic physical activity in reducing the frequency of hepatic steatosis and metabolic and cardiovascular risk in postmenopausal women with nonalcoholic fatty liver disease (NAFLD).
Forty sedentary postmenopausal women (mean age 55.3 ± 8.0 y) with biopsy-proven NAFLD were randomly divided into two groups: an exercising group (19 participants) and a control group (nonexercising, 21 participants). The exercise group underwent a supervised aerobic physical activity program of 120 min/wk for 24 weeks. The anthropometric parameters; body composition; hepatic, lipid, and glycemic profiles; homeostasis model assessment of insulin resistance index; cytokines; transient elastography (FibroScan; liver stiffness/controlled attenuation parameter); and cardiopulmonary exercise test were evaluated at baseline and after 24 weeks of protocol.
At baseline there were no significant differences in anthropometric, metabolic, and inflammatory parameters-stiffness and liver fat content by FibroScan between the groups. After 24 weeks, we observed a decrease of waist circumference, an increase of high-density lipoprotein cholesterol levels (P < 0.05), and improved cardiopulmonary functional capacity in the exercise group. In addition, the controlled attenuation parameter analysis showed no significant decrease of hepatic steatosis in the exercise group. With regard to the systemic inflammation, there were, however, no significant differences in the cytokines between the groups.
An aerobic physical activity program of 24 weeks in NAFLD postmenopausal women showed improvement in some variables such as waist circumference, high-density lipoprotein cholesterol, and cardiopulmonary performance that may be beneficial in improving cardiovascular risk factors in this population.
本研究旨在评估有氧运动对降低绝经后非酒精性脂肪性肝病（NAFLD）女性肝脂肪变性频率以及代谢和心血管风险的有效性。
40名经活检证实患有NAFLD的久坐绝经后女性（平均年龄55.3±8.0岁）被随机分为两组：运动组（19名参与者）和对照组（不运动，21名参与者）。运动组接受为期24周、每周120分钟的有监督有氧运动计划。在基线时以及方案实施24周后，评估人体测量参数、身体成分、肝脏、脂质和血糖谱、胰岛素抵抗指数的稳态模型评估、细胞因子、瞬时弹性成像（FibroScan；肝脏硬度/控制衰减参数）以及心肺运动试验。
在基线时，两组之间在人体测量、代谢和炎症参数（通过FibroScan测量的硬度和肝脏脂肪含量）方面没有显著差异。24周后，我们观察到运动组腰围减小、高密度脂蛋白胆固醇水平升高（P<0.05）以及心肺功能能力改善。此外，控制衰减参数分析显示运动组肝脂肪变性没有显著降低。然而，关于全身炎症，两组之间的细胞因子没有显著差异。
NAFLD绝经后女性进行24周的有氧运动计划可使一些变量得到改善，如腰围、高密度脂蛋白胆固醇和心肺功能，这可能有助于改善该人群的心血管危险因素。
