Beijing Normal University College of Physical Education and Sport, Beijing, China.
Physical Education Department, Northeastern University, Shenyang, Liaoning, China.
Sci Rep. 2024 Mar 14;14(1):6212. doi: 10.1038/s41598-024-51470-4.
Physical exercise intervention can significantly improve the liver of patients with Non-alcoholic fatty liver disease (NAFLD), but it is unknown which exercise mode has the best effect on liver improvement in NAFLD patients. Therefore, we systematically evaluated the effect of exercise therapy on liver and blood index function of NAFLD patients through network meta-analysis (NMA). Through systematic retrieval of PubMed, Cochrane Library, Web of Science, EBSCO, and CNKI (National Knowledge Infrastructure), two reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies by means of databases from inception to January 2023. The NMA was performed using the inconsistency model. A total of 43 studies, 2070 NAFLD patients were included: aerobic training (n = 779), resistance training (n = 159), high-intensity interval training (n = 160), aerobic training + resistance training (n = 96). The results indicate that aerobic training + resistance training could significantly improve serum total cholesterol (TC) (Surface under the cumulative ranking curve (SUCRA) = 71.7), triglyceride (TG) (SUCRA = 96.8), low-density lipoprotein cholesterol (LDL-C) (SUCRA = 86.1) in patients with NAFLD including triglycerides. Aerobic training is the best mode to improve ALT (SUCRA = 83.9) and high-density lipoprotein cholesterol (HDL-C) (SUCRA = 72.3). Resistance training is the best mode to improve aspartate transaminase (AST) (SUCRA = 81.7). Taking various benefits into account, we believe that the best modality of exercise for NAFLD patients is aerobic training + resistance training. In our current network meta-analysis, these exercise methods have different effects on the six indicators of NAFLD, which provides some reference for further formulating exercise prescription for NAFLD patients.
身体锻炼干预可以显著改善非酒精性脂肪性肝病(NAFLD)患者的肝脏,但尚不清楚哪种运动模式对改善 NAFLD 患者的肝脏最有效。因此,我们通过网络荟萃分析(NMA)系统地评估了运动疗法对 NAFLD 患者肝脏和血液指标功能的影响。通过系统检索 PubMed、Cochrane 图书馆、Web of Science、EBSCO 和中国知网(CNKI),两名审查员独立筛选文献、提取数据,并通过数据库对纳入研究进行偏倚风险评估,时间范围从建库至 2023 年 1 月。采用不一致模型进行 NMA。共纳入 43 项研究,2070 例 NAFLD 患者:有氧运动训练(n=779)、抗阻训练(n=159)、高强度间歇训练(n=160)、有氧运动训练+抗阻训练(n=96)。结果表明,有氧运动训练+抗阻训练可显著改善血清总胆固醇(TC)(累积排序曲线下面积(SUCRA)=71.7)、三酰甘油(TG)(SUCRA=96.8)、低密度脂蛋白胆固醇(LDL-C)(SUCRA=86.1)在包括甘油三酯的 NAFLD 患者中。有氧运动是改善丙氨酸氨基转移酶(ALT)(SUCRA=83.9)和高密度脂蛋白胆固醇(HDL-C)(SUCRA=72.3)的最佳模式。抗阻训练是改善天冬氨酸氨基转移酶(AST)(SUCRA=81.7)的最佳模式。综合考虑各种益处,我们认为 NAFLD 患者最佳的运动模式是有氧运动+抗阻训练。在我们目前的网络荟萃分析中,这些运动方法对 NAFLD 的六个指标有不同的影响,为进一步为 NAFLD 患者制定运动处方提供了一些参考。