Kumar Saurabh, Grundeis Felicitas, Brand Cristin, Hwang Han-Jeong, Mehnert Jan, Pleger Burkhard
Max Planck Institute for Human Cognitive and Brain SciencesLeipzig, Germany; Day Clinic for Cognitive Neurology, University Hospital LeipzigLeipzig, Germany.
Max Planck Institute for Human Cognitive and Brain SciencesLeipzig, Germany; Day Clinic for Cognitive Neurology, University Hospital LeipzigLeipzig, Germany; Kumoh National Institute of Technology, Department of Medical IT Convergence EngineeringGumi, South Korea.
Front Hum Neurosci. 2016 May 20;10:233. doi: 10.3389/fnhum.2016.00233. eCollection 2016.
Brain regions involved in the reappraisal of tasty but unhealthy foods are of special interest for the development of new therapeutic interventions for obesity, such as non-invasive brain stimulation or neurofeedback. Here, we visually presented food items (i.e., high/low caloric) to obese and lean individuals during electroencephalogram (EEG) recordings, while they either admitted or regulated their food desire. During admitting the desire for low and high calorie foods, obese as well as lean individuals showed higher activity in the left dorsolateral prefrontal cortex (DLPFC), whereas the right frontal operculum was involved in the reappraisal of the same foods, suggesting interplay between executive control and gustatory regions. Only in lean participants, we found an interaction between calorie content and the regulate/admit conditions in bilateral anterior insular cortices, suggesting that the anterior insula, assumed to primarily host gustatory processes, also underpins higher cognitive processes involved in food choices, such as evaluating the foods' calorie content for its reappraisal.
参与重新评估美味但不健康食物的脑区对于开发肥胖症新治疗干预措施（如非侵入性脑刺激或神经反馈）具有特殊意义。在此，我们在脑电图（EEG）记录期间向肥胖和瘦个体视觉呈现食物项目（即高热量/低热量），同时他们要么承认要么调节自己的食物欲望。在承认对低热量和高热量食物的欲望时，肥胖个体和瘦个体在左侧背外侧前额叶皮层（DLPFC）均表现出较高的活动，而右侧额下回参与了对相同食物的重新评估，这表明执行控制和味觉区域之间存在相互作用。仅在瘦参与者中，我们发现双侧前岛叶皮层中卡路里含量与调节/承认条件之间存在相互作用，这表明假定主要承载味觉过程的前岛叶也支持食物选择中涉及的更高认知过程，例如评估食物的卡路里含量以进行重新评估。
