Kumar Saurabh, Grundeis Felicitas, Brand Cristin, Hwang Han-Jeong, Mehnert Jan, Pleger Burkhard
Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1, 04103, Leipzig, Germany.
Collaborative Research Centre 1052 "Obesity Mechanisms", University Hospital Leipzig, Liebigstraße 18, 04103, Leipzig, Germany.
Exp Brain Res. 2018 Oct;236(10):2553-2562. doi: 10.1007/s00221-018-5318-z. Epub 2018 Jun 22.
In the present pilot study, we questioned how eating to satiety affects cognitive influences on the desire for food and corresponding neuronal activity in the obese female brain. During EEG recording, lean (n = 10) and obese women (n = 10) self-rated the ability to reappraise visually presented food. All women were measured twice, when hungry and after eating to satiety. After eating to satiety, reappraisal of food was easier than when being hungry. Comparing the EEG data of the sated to the hungry state, we found that only in obese women the frontal operculum was involved not only in the reappraisal of food but also in admitting the desire for the same food. The right frontal operculum in the obese female brain, assumed to primarily host gustatory processes, may be involved in opposing cognitive influences on the desire for food. These findings may help to find potential brain targets for non-invasive brain stimulation or neurofeedback studies that aim at modulating the desire for food.
在本试点研究中，我们探究了吃到饱腹感如何影响肥胖女性大脑中对食物渴望的认知影响及相应的神经元活动。在脑电图记录过程中，体重正常的女性（n = 10）和肥胖女性（n = 10）对重新评估视觉呈现食物的能力进行了自我评估。所有女性在饥饿时和吃到饱腹感后各测量了一次。吃到饱腹感后，对食物的重新评估比饥饿时更容易。将饱腹状态与饥饿状态的脑电图数据进行比较，我们发现只有肥胖女性的额下回不仅参与了对食物的重新评估，还参与了承认对相同食物的渴望。肥胖女性大脑中的右侧额下回，被认为主要负责味觉处理，可能参与了对抗对食物渴望的认知影响。这些发现可能有助于找到针对非侵入性脑刺激或神经反馈研究的潜在脑靶点，这些研究旨在调节对食物的渴望。
