Li Yu-Ling, Zhao Hua, Ren Xiu-Bao
Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Key Laboratory of Cancer Immunology and Biotherapy, Research Center of Lung Cancer, Tianjin 300060, China.
Cancer Biol Med. 2016 Jun;13(2):206-14. doi: 10.20892/j.issn.2095-3941.2015.0070.
Vascular endothelial growth factor (VEGF) is primarily known as a proangiogenic factor and is one of the most important growth and survival factors affecting the vascular endothelium. However, recent studies have shown that VEGF also plays a vital role in the immune environment. In addition to the traditional growth factor role of VEGF and VEGF receptors (VEGFRs), they have a complicated relationship with various immune cells. VEGF also reportedly inhibits the differentiation and function of immune cells during hematopoiesis. Dendritic cells (DCs), macrophages, and lymphocytes further express certain types of VEGF receptors. VEGF can be secreted as well by tumor cells through the autocrine pathway and can stimulate the function of cancer stemness. This review will provide a paradigm shift in our understanding of the role of VEGF/VEGFR signaling in the immune and cancer environment.
血管内皮生长因子(VEGF)主要被认为是一种促血管生成因子,是影响血管内皮的最重要的生长和存活因子之一。然而,最近的研究表明,VEGF在免疫环境中也起着至关重要的作用。除了VEGF和VEGF受体(VEGFRs)的传统生长因子作用外,它们与各种免疫细胞有着复杂的关系。据报道,VEGF在造血过程中还会抑制免疫细胞的分化和功能。树突状细胞(DCs)、巨噬细胞和淋巴细胞进一步表达某些类型的VEGF受体。肿瘤细胞也可以通过自分泌途径分泌VEGF,并能刺激癌症干性的功能。本综述将为我们对VEGF/VEGFR信号在免疫和癌症环境中的作用的理解带来范式转变。