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Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects.

作者信息

Franks Paul W, Pearson Ewan, Florez Jose C

机构信息

Department of Clinical Science, Lund University, Malmö, Sweden.

出版信息

Diabetes Care. 2013 May;36(5):1413-21. doi: 10.2337/dc12-2211.

DOI:10.2337/dc12-2211
PMID:23613601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3631878/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b831/3631878/8cf3a419d1f4/1413fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b831/3631878/810b3f75ab3f/1413fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b831/3631878/8cf3a419d1f4/1413fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b831/3631878/810b3f75ab3f/1413fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b831/3631878/8cf3a419d1f4/1413fig2.jpg

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本文引用的文献

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Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.对 15 个队列数据中与葡萄糖稳态相关的基因座进行分析，以探讨健康饮食与空腹血糖和胰岛素水平之间的关联及其修饰作用的荟萃分析。
Am J Epidemiol. 2013 Jan 15;177(2):103-15. doi: 10.1093/aje/kws297. Epub 2012 Dec 19.
2
Sugar-sweetened beverages and genetic risk of obesity.含糖饮料与肥胖的遗传风险。
N Engl J Med. 2012 Oct 11;367(15):1387-96. doi: 10.1056/NEJMoa1203039. Epub 2012 Sep 21.
3
FTO genotype is associated with phenotypic variability of body mass index.
遗传风险评分与饮食脂肪摄入量对巴西年轻成年人脂质相关特征的相互作用。
Br J Nutr. 2024 Sep 14;132(5):575-589. doi: 10.1017/S0007114524001594. Epub 2024 Sep 23.
4
A Systematic Review of the Effect of Gene-Lifestyle Interactions on Metabolic-Disease-Related Traits in South Asian Populations.南亚人群中基因-生活方式相互作用对代谢疾病相关性状影响的系统评价
Nutr Rev. 2025 Jun 1;83(6):1061-1082. doi: 10.1093/nutrit/nuae115.
5
CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant.CRISPR 筛选揭示了胰腺分化中 ONECUT1 的长程增强子，并将一个糖尿病风险变异与该增强子联系起来。
Cell Rep. 2024 Aug 27;43(8):114640. doi: 10.1016/j.celrep.2024.114640. Epub 2024 Aug 21.
6
Haplotype analysis on association between C-reactive protein gene and susceptibility to type 2 diabetes mellitus in Chinese Han population : CRP gene and type 2 diabetes mellitus.中国汉族人群 C 反应蛋白基因与 2 型糖尿病易感性的单体型分析：CRP 基因与 2 型糖尿病。
Acta Diabetol. 2024 Nov;61(11):1423-1432. doi: 10.1007/s00592-024-02309-x. Epub 2024 Jun 4.
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Examination of the Complex Molecular Landscape in Obesity and Type 2 Diabetes.肥胖症和 2 型糖尿病中复杂分子谱的研究。
Int J Mol Sci. 2024 Apr 27;25(9):4781. doi: 10.3390/ijms25094781.
8
Ancestry-attenuated effects of socioeconomic deprivation on type 2 diabetes disparities in the cohort.在该队列中，社会经济剥夺对2型糖尿病差异的血统减弱效应。
BMC Glob Public Health. 2023;1. doi: 10.1186/s44263-023-00025-2. Epub 2023 Nov 6.
9
Gene-diet interaction analysis using novel weighted food scores discovers the adipocytokine signaling pathway associated with the development of type 2 diabetes.利用新型加权食物评分进行基因-饮食相互作用分析，发现与 2 型糖尿病发展相关的脂肪细胞因子信号通路。
Front Endocrinol (Lausanne). 2023 Aug 23;14:1165744. doi: 10.3389/fendo.2023.1165744. eCollection 2023.
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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.大规模的关联分析确定了影响血糖特征的新基因座，并深入了解了潜在的生物学途径。
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PLoS Genet. 2012 May;8(5):e1002741. doi: 10.1371/journal.pgen.1002741. Epub 2012 May 31.
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