Laboratorio de Investigación en COVID-19, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.
Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.
Int J Mol Sci. 2024 Feb 10;25(4):2134. doi: 10.3390/ijms25042134.
(Kpn) is an opportunistic pathogen that causes intrahospital complications such as pneumonia, liver abscesses, soft tissue infections, urinary infections, bacteraemia, and, in some cases, death. Since this bacterium has a higher frequency than other Gram-negative pathogens, it has become an important pathogen to the health sector. The adaptative genome of Kpn likely facilitates increased survival of the pathogen in diverse situations. Therefore, several studies have been focused on developing new molecules, synergistic formulations, and biomaterials that make it possible to combat and control infections with and dispersion of this pathogen. Note that the uncontrolled antibiotic administration that occurred during the pandemic led to the emergence of new multidrug-resistant strains, and scientists were challenged to overcome them. This review aims to compile the latest information on Kpn that generates intrahospital infections, specifically their pathogenicity-associated factors. Furthermore, it explains the natural-product-based treatments (extracts and essential oils) developed for Kpn infection and dispersion control.
(Kpn)是一种机会性病原体,可导致院内并发症,如肺炎、肝脓肿、软组织感染、尿路感染、菌血症,在某些情况下还可导致死亡。由于该细菌比其他革兰氏阴性病原体更为常见,因此已成为卫生部门的重要病原体。Kpn 的适应性基因组可能有助于该病原体在各种情况下更好地存活。因此,已经有多项研究致力于开发新的分子、协同制剂和生物材料,以对抗和控制这种病原体的感染和传播。值得注意的是,大流行期间抗生素的不受控制使用导致了新的多药耐药菌株的出现,这对科学家们提出了挑战。本综述旨在汇编与院内感染相关的最新 Kpn 信息,特别是与其致病性相关的因素。此外,它还解释了针对 Kpn 感染和传播控制而开发的基于天然产物的治疗方法(提取物和精油)。