通过 N-（五氟苯甲酰氧基）磺酰胺的氮杂-Heck 环化反应构建多样的 N-杂环体系。
Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides.
机构信息
School of Chemistry, University of Bristol, Bristol, BS8 1TS, United Kingdom.
Pharmaceutical Technology & Development, AstraZeneca, Charter Way, Macclesfield, SK10 2NA, United Kingdom.
出版信息
Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11198-11202. doi: 10.1002/anie.201605152. Epub 2016 Jul 27.
Abstract
Aza-Heck cyclizations initiated by oxidative addition of Pd(0) -catalysts into the N-O bond of N-(pentafluoro-benzoyloxy)sulfonamides are described. These studies, which encompass only the second class of aza-Heck reaction developed to date, provide direct access to diverse N-heterocyclic ring systems.
摘要
钯（0）催化剂对 N-(全氟苯甲酰氧基)磺酰胺 N-O 键的氧化加成引发的 Aza-Heck 环化反应被描述。这些研究涵盖了迄今为止开发的第二类 Aza-Heck 反应，为各种 N-杂环体系提供了直接途径。
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