Department of Periodontology, University Hospital Würzburg, Würzburg, Germany.
German Naval Medical Institute, Kronshagen, Germany.
J Periodontol. 2020 Oct;91(10):1328-1338. doi: 10.1002/JPER.19-0393. Epub 2020 Feb 26.
The objective of this trial was to evaluate whether the regular consumption of probiotics may improve the known deterioration of periodontal health in navy sailors during deployments at sea.
72 healthy sailors of a naval ship on a practicing mission at sea were recruited and randomly provided with a blinded supply of lozenges to be consumed twice daily for the following 42 days containing either the probiotic strains Lactobacillus reuteri (DSM 17938 and L. reuteri (ATTC PTA 5289) (test n = 36) or no probiotics (placebo n = 36). At baseline, at day 14 and day 42 bleeding on probing (primary outcome), gingival index, plaque control record, probing attachment level, and probing pocket depth were assessed at the Ramfjord teeth.
At baseline there were no significant differences between the groups. At day 14 and day 42 test group scores of all assessed parameters were significantly improved (P < 0.001) compared to baseline and to the placebo group which by contrast showed a significant (P < 0.001) deterioration of all parameters at the end of the study.
The consumption of probiotic L. reuteri-lozenges is an efficacious measure to improve and maintain periodontal health in situations with waning efficacy of personal oral hygiene.
本试验旨在评估常规食用益生菌是否可以改善海军水手在海上部署期间已知的牙周健康恶化。
招募了一艘正在进行海上实习任务的海军舰艇上的 72 名健康水手，并随机提供了盲法供应的含片，供水手们在接下来的 42 天内每天服用两次，每次含有的益生菌菌株为罗伊氏乳杆菌（DSM 17938 和 L. reuteri（ATTC PTA 5289）（试验组 n=36）或不含益生菌（安慰剂 n=36）。在基线、第 14 天和第 42 天，用 Ramfjord 牙齿评估探诊出血（主要结局）、牙龈指数、菌斑控制记录、探诊附着水平和探诊袋深度。
基线时两组间无显著差异。在第 14 天和第 42 天，试验组所有评估参数的评分均显著改善（P<0.001），与基线相比，与安慰剂组相比，在研究结束时所有参数均显著恶化（P<0.001）。
食用益生菌罗伊氏乳杆菌含片是改善和维持牙周健康的有效措施，特别是在个人口腔卫生效果减弱的情况下。
