Spugnini Enrico P, Fais Stefano, Azzarito Tommaso, Baldi Alfonso
Biopulse srl, Naples, Italy.
Department of Therapeutic Research and Medicines Evaluation, National Institute of Health, Rome, Italy.
J Cell Physiol. 2017 Mar;232(3):490-495. doi: 10.1002/jcp.25505. Epub 2016 Oct 27.
Electrochemotherapy (ECT) is a medical strategy that allows an increased efficacy of chemotherapy agents after the application of permeabilizing electric pulses having appropriate characteristics (form, voltage, frequency). In the past 10 years, the clinical efficacy of this therapeutic approach in several spontaneous models of tumors in animals has been shown. Moreover, some of the molecular and cellular mechanisms responsible for this phenomenon have been elucidated. Our group has been deeply involved in the development of new ECT protocols for companion animals, implementing the use of the technique as first line treatment, and evaluating different chemotherapy agents in laboratory animals as well as pets. This article summarizes the most important advances in veterinary ECT, including the development of novel equipment, therapeutic protocols, and their translation to humans. J. Cell. Physiol. 232: 490-495, 2017. © 2016 Wiley Periodicals, Inc.
电化学疗法（ECT）是一种医学策略，在施加具有适当特性（形式、电压、频率）的透化电脉冲后，可提高化疗药物的疗效。在过去10年中，这种治疗方法在几种动物自发性肿瘤模型中的临床疗效已得到证实。此外，一些导致这种现象的分子和细胞机制也已被阐明。我们的团队一直深度参与伴侣动物新型ECT方案的开发，将该技术作为一线治疗方法加以应用，并在实验动物以及宠物中评估不同的化疗药物。本文总结了兽医ECT领域最重要的进展，包括新型设备、治疗方案的开发以及它们向人类医学领域的转化。《细胞生理学杂志》232: 490 - 495, 2017。© 2016威利期刊公司
