台湾中老年人群中尿酸与代谢综合征的关联：一项基于社区的横断面研究。
The Association between Uric Acid and Metabolic Syndrome in a Middle-Aged and Elderly Taiwanese Population: A Community-Based Cross-Sectional Study.
作者信息
Lin Chun-Ru, Tsai Po-An, Wang Che, Chen Jau-Yuan
机构信息
Department of Medical Education, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing Street, Guishan District, Taoyuan City 333423, Taiwan.
Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan City 333423, Taiwan.
出版信息
Healthcare (Basel). 2024 Jan 3;12(1):113. doi: 10.3390/healthcare12010113.
BACKGROUND
Metabolic syndrome (MetS) is a prevalent health condition in Taiwan that places individuals at higher risk of cardiovascular disease, diabetes, and stroke. Therefore, the identification of risk factors associated with MetS is crucial. The aim of this study was to investigate the association of uric acid and MetS in a Taiwanese community with a middle-aged and elderly population.
METHODS
This cross-sectional study enrolled residents aged 50-90 years living in one community. All of the subjects received a standardized personal interview, including a structured questionnaire, anthropometric measurements, and blood samples were collected for laboratory testing. MetS was defined as excess waist circumference, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Multiple logistic regression models were used to evaluate uric acid tertiles associated with MetS.
RESULTS
A total of 400 subjects were enrolled in the analysis. The overall prevalence of MetS was 35.8%. The prevalence of MetS increased gradually with increasing serum uric acid levels ( value < 0.001). A significant association between uric acid and cardiometabolic risk factors was confirmed, with a Pearson's correlation coefficient for waist circumference of 0.30 ( < 0.001), a coefficient for systolic blood pressure of 0.13 ( = 0.01), a coefficient for triglycerides of 0.33 ( < 0.001), and a coefficient for high-density lipoprotein of -0.30 ( < 0.001). The adjusted odds ratio (OR) of the high uric acid tertile level for MetS was 2.48 (95% CI = 1.31-4.71, = 0.01). The area under the ROC curve (AUC) for uric acid in predicting MetS was 0.621 ( < 0.001).
CONCLUSIONS
The prevalence of MetS in our study population is high. High serum uric acid levels are independently associated with the presence of MetS among the middle-aged and elderly Taiwanese population.
背景
代谢综合征（MetS）在台湾是一种普遍的健康状况，使个体患心血管疾病、糖尿病和中风的风险更高。因此，识别与代谢综合征相关的危险因素至关重要。本研究的目的是调查台湾一个中老年社区中尿酸与代谢综合征之间的关联。
方法
这项横断面研究纳入了居住在一个社区的50 - 90岁居民。所有受试者都接受了标准化的个人访谈，包括结构化问卷、人体测量，并且采集血样进行实验室检测。代谢综合征的定义为腰围超标、高血压、高血糖、高血清甘油三酯和低血清高密度脂蛋白（HDL）。使用多个逻辑回归模型来评估与代谢综合征相关的尿酸三分位数。
结果
共有400名受试者纳入分析。代谢综合征的总体患病率为35.8%。代谢综合征的患病率随着血清尿酸水平的升高而逐渐增加（P值<0.001）。证实尿酸与心脏代谢危险因素之间存在显著关联，腰围的Pearson相关系数为0.30（P<0.001），收缩压系数为0.13（P = 0.01），甘油三酯系数为0.33（P<0.001），高密度脂蛋白系数为 - 0.30（P<0.001）。代谢综合征高尿酸三分位数水平的调整优势比（OR）为2.48（95%CI = 1.31 - 4.71，P = 0.01）。尿酸预测代谢综合征的ROC曲线下面积（AUC）为0.621（P<0.001）。
结论
我们研究人群中代谢综合征的患病率很高。高血清尿酸水平在台湾中老年人群中与代谢综合征的存在独立相关。
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