Monika Padmanabhan, Geetha Arumugam
Indian J Exp Biol. 2016 Jun;54(6):370-8.
The fruits of Persea Americana Mill., commonly known as Avocado, are traditionally consumed for various health benefits including weight reduction. Here, we studied the effect of hydroalcoholic fruit extract of Persea americana (HAEPA) on high fat diet (HFD) induced obesity in rats. Obesity was induced in male Sprague Dawley rats by feeding HFD for 14 wk. The hypolipidemic effect was evaluated by co-administering 25, 50, 100 and 200 mg/kg body wt. of HAEPA. There was a significant increase in weight gain, body mass index (BMI), blood lipids, low density lipoproteins (LDL), lipid peroxides (LPO) and serum transaminases in HFD fed rats. HFD+HAEPA fed rats showed a significant decrease in blood lipids, LPO, liver lipids and increase in antioxidant status when compared to HFD control rats. The activity of lipid metabolic key enzymes such as fatty acid synthase and HMG CoA reductase in liver were also found to be decreased significantly in HAEPA co-administered rats. Lipoprotein lipase activity was found increased in HFD+HAEPA rats. Among the 4 doses studied, 100 mg of HAEPA/kg body wt. exhibited optimum hypolipidemic activity. Histopathological observations in liver and visceral adipose tissue added more evidence for the lipid lowering effect of HAEPA. It can be concluded that avocado fruit extract can act as hypolipidemic agent probably by modulating the activities of HMG CoA reductase and fatty acid synthase in liver.
鳄梨（Persea Americana Mill.），通常被称为牛油果，其果实传统上因具有多种健康益处（包括有助于减肥）而被食用。在此，我们研究了鳄梨水醇提取物（HAEPA）对高脂饮食（HFD）诱导的大鼠肥胖的影响。通过给雄性斯普拉格-道利大鼠喂食高脂饮食14周来诱导肥胖。通过共同给予25、50、100和200毫克/千克体重的HAEPA来评估其降血脂作用。喂食高脂饮食的大鼠体重增加、体重指数（BMI）、血脂、低密度脂蛋白（LDL）、脂质过氧化物（LPO）和血清转氨酶显著增加。与高脂饮食对照组大鼠相比，喂食高脂饮食+HAEPA的大鼠血脂、LPO、肝脏脂质显著降低，抗氧化状态增加。在共同给予HAEPA的大鼠中，还发现肝脏中脂肪酸合酶和HMG CoA还原酶等脂质代谢关键酶的活性显著降低。在喂食高脂饮食+HAEPA的大鼠中发现脂蛋白脂肪酶活性增加。在所研究的4个剂量中,100毫克/千克体重的HAEPA表现出最佳的降血脂活性。肝脏和内脏脂肪组织的组织病理学观察为HAEPA的降脂作用提供了更多证据。可以得出结论，鳄梨果实提取物可能通过调节肝脏中HMG CoA还原酶和脂肪酸合酶的活性而起到降血脂剂的作用。
