Kang Chen, Sun Yuan, Zhu Jing, Li Wen, Zhang Aili, Kuang Tairong, Xie Jing, Yang Zhaogang
Institute of Life Sciences, Jilin University, Changchun, Jilin, 130012 China.
Department of Chemical and Biomolecular Engineering, 481 CBEC, 151 W. Woodruff Ave, Columbus, OH, USA.
Curr Drug Metab. 2016;17(8):745-754. doi: 10.2174/1389200217666160728152939.
Malignant brain tumor is a highly challenging disease for diagnosis, treatment, and management. Cytotoxicity, distribution and the ability to cross blood brain barrier are some of the most significant issues for the chemotherapy of brain tumors. Nanotechnology has been widely exploited in drug delivery with great potential in improving the drug efficiency and efficacy. The advent of nanotechnology would greatly facilitate the early detection and treatment of brain tumors. This review will be primarily focused on current nano drug delivery system for brain cancer therapy. Meanwhile, the existing impediments for therapeutic nanomedicines and critical analysis of the different delivery nanoparticles are also discussed.
We systematically evaluated the major factors that impact the current nanomedicines for brain tumor therapy. Meanwhile, various nanoparticle-based formulations for brain cancer detection and therapy are evaluated.
124 papers were included in this review. From the analysis of the nanomaterials, seven major nanomaterials have been discussed regarding the functionality and current therapeutic significance. The review also explains in detail about the different types of nanomaterials and their functionalities. This shows that each of these nanomaterials has specialized functions for the treatment of various kinds of brain cancer.
Nanomaterials provide a viable potential diagnosis mechanis. In the future, more research needs to be focused on developing a better diagnosis tool for detection of cancer on an urgent basis. Blood-brain barrier and cytotoxicity are some of the primary root causes for the impediment of treatment of cancer using nanoparticles. Therefore, different delivery systems should be exploited for the nanoparticles to surmount these issues.
恶性脑肿瘤在诊断、治疗和管理方面是极具挑战性的疾病。细胞毒性、分布以及穿越血脑屏障的能力是脑肿瘤化疗中一些最为关键的问题。纳米技术已在药物递送中得到广泛应用，在提高药物效率和疗效方面具有巨大潜力。纳米技术的出现将极大地促进脑肿瘤的早期检测和治疗。本综述将主要聚焦于当前用于脑癌治疗的纳米药物递送系统。同时，还讨论了治疗性纳米药物存在的障碍以及对不同递送纳米颗粒的批判性分析。
我们系统地评估了影响当前用于脑肿瘤治疗的纳米药物的主要因素。同时，评估了各种基于纳米颗粒的用于脑癌检测和治疗的制剂。
本综述纳入了124篇论文。通过对纳米材料的分析，讨论了七种主要纳米材料的功能及当前的治疗意义。该综述还详细解释了不同类型的纳米材料及其功能。这表明这些纳米材料中的每一种对于治疗各种类型的脑癌都具有特定功能。
纳米材料提供了一种可行的潜在诊断机制。未来，迫切需要更多研究聚焦于开发更好的癌症检测诊断工具。血脑屏障和细胞毒性是使用纳米颗粒治疗癌症的主要障碍根源。因此，应开发不同的递送系统以使纳米颗粒克服这些问题。
