一种基于ATP-荧光共振能量转移的双光子荧光探针，用于对活细胞和组织线粒体中的内源性二氧化硫衍生物进行比率可视化。
A TP-FRET-based two-photon fluorescent probe for ratiometric visualization of endogenous sulfur dioxide derivatives in mitochondria of living cells and tissues.
作者信息
Yang Xiaoguang, Zhou Yibo, Zhang Xiufang, Yang Sheng, Chen Yun, Guo Jingru, Li Xiaoxuan, Qing Zhihe, Yang Ronghua
机构信息
School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha, 410114, China.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
出版信息
Chem Commun (Camb). 2016 Aug 11;52(67):10289-92. doi: 10.1039/c6cc05254a.
A ratiometric two-photon fluorescent probe for SO2 derivatives was first proposed based on acedan-merocyanine dyads via a TP-FRET strategy. It was successfully applied to visualization of the fluctuations of enzymatically generated SO2 derivatives in the mitochondria of HepG2 cells and rat liver tissues using two-photon fluorescence microscopy imaging.
基于吖啶-部花青二元体系，通过双光子荧光共振能量转移（TP-FRET）策略首次提出了一种用于检测二氧化硫衍生物的比率型双光子荧光探针。利用双光子荧光显微镜成像技术，该探针成功应用于可视化HepG2细胞线粒体和大鼠肝脏组织中酶促生成的二氧化硫衍生物的波动情况。
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