Jenkins Taylor M, Rosenbaum Jason, Zhang Paul J, Schwartz Lauren E, Nayak Anupma, Cooper Kumarasen, Tickoo Satish K, Lal Priti
1 Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
2 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Int J Surg Pathol. 2019 Sep;27(6):678-683. doi: 10.1177/1066896919845490. Epub 2019 Apr 28.
Thyroid-like follicular carcinoma of the kidney (TLFCK) is an extremely rare primary renal malignancy that typically has an indolent course and good prognosis. Histologically, this tumor mimics follicular carcinoma of the thyroid; however, typical thyroid markers are negative. There are fewer than 40 cases reported in the literature, and thus, the prognosis and course of disease is not well understood. Sarcomatoid differentiation has never been reported in a case of TLFCK. We present a case of a 48-year-old woman with an aggressive TLFCK with extensive sarcomatoid differentiation and metastatic disease at presentation. We performed targeted next-generation sequencing of both the thyroid-like component and the poorly differentiated sarcomatoid component using our solid tumor panel to evaluate for any disease-associated mutations and to better understand the molecular profile of these tumors.
肾甲状腺样滤泡癌（TLFCK）是一种极其罕见的原发性肾恶性肿瘤，通常病程惰性，预后良好。组织学上，这种肿瘤类似于甲状腺滤泡癌；然而，典型的甲状腺标志物为阴性。文献报道的病例少于40例，因此，疾病的预后和病程尚不清楚。TLFCK病例中从未有过肉瘤样分化的报道。我们报告一例48岁女性，患有侵袭性TLFCK，就诊时伴有广泛的肉瘤样分化和转移性疾病。我们使用实体瘤检测板对甲状腺样成分和低分化肉瘤样成分进行了靶向二代测序，以评估是否存在任何与疾病相关的突变，并更好地了解这些肿瘤的分子特征。
