Agrawal Vinita, Neyaz Zafar, Kapoor Rakesh
Department of Pathology, 30093Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Radiodiagnosis, 30093Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Int J Surg Pathol. 2020 Dec;28(8):913-917. doi: 10.1177/1066896920930283. Epub 2020 Jun 2.
Thyroid-like follicular carcinoma of kidney (TLFCK) is a morphological subtype of renal cell carcinoma, which is included as an emerging/provisional entity in the classification of renal tumors, with only about 40 cases reported in literature. It has a distinct histological appearance and immunohistochemical profile as compared with other renal cell cancers. However, these tumors, while appearing distinctive, have not been characterized fully either morphologically or by ancillary techniques. The reported cases show variable demographical and clinical features. Most are indolent, while some present with metastasis. The histological, immunohistochemical, and ultrastructural features of a case of TLFCK with clusters of oncocytic cells and pseudosarcomatous stroma are presented. Follow-up of 5 years was uneventful. A review of literature to analyze features in metastatic as compared with non-metastatic TLFCK is discussed. We report a patient of TLFCK and compare the clinicopathological features of metastatic and non-metastatic tumors.
肾甲状腺样滤泡癌(TLFCK)是肾细胞癌的一种形态学亚型,在肾肿瘤分类中作为一种新出现的/暂定的实体,文献中仅报道了约40例。与其他肾细胞癌相比,它具有独特的组织学表现和免疫组化特征。然而,这些肿瘤虽然表现独特,但在形态学或辅助技术方面均未得到充分表征。报道的病例显示出不同的人口统计学和临床特征。大多数病例进展缓慢,而有些则出现转移。本文介绍了一例伴有嗜酸性细胞簇和假肉瘤样间质的TLFCK的组织学、免疫组化和超微结构特征。5年随访无异常。讨论了对文献的回顾,以分析转移性与非转移性TLFCK的特征。我们报告了一例TLFCK患者,并比较了转移性和非转移性肿瘤的临床病理特征。