Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, Unité Mixte de Recherche 5305, Université Lyon 1, Centre National de la Recherche Scientifique (CNRS), Institut de Biologie et Chimie des Protéines (IBCP)-Lyon, France; InvivoGen, Toulouse, France; Groupe Immunité des Muqueuses et Agents Pathogènes, Institut National de la Santé et de la Recherche Médicale (INSERM) Centre d'Investigation Clinique 1408 Vaccinologie, Faculté de Médecine de Saint-Etienne-Saint-Etienne, France.
InvivoGen, Toulouse, France.
Trends Immunol. 2016 Sep;37(9):573-587. doi: 10.1016/j.it.2016.07.001. Epub 2016 Jul 27.
Immune adjuvants are components that stimulate, potentiate, or modulate the immune response to an antigen. They are key elements of vaccines in both the prophylactic and therapeutic domains. In the past decade substantial progress in our understanding of innate immunity has paved the way for the design of next-generation adjuvants that stimulate a wide range of receptors. Within the framework of vaccine adjuvant design, this review outlines the interest of targeting endosomal and intracellular receptors to enhance and guide the immune response. We present and compare the molecules as well as potential combinations which are currently in the spotlight. We emphasize how targeting the appropriate receptor can direct immunity towards the appropriate response, such as a cytotoxic or mucosal response.
免疫佐剂是指能够刺激、增强或调节抗原免疫反应的成分。它们是预防性和治疗性疫苗领域的关键要素。在过去的十年中，我们对先天免疫的理解取得了重大进展，为设计能够刺激广泛受体的下一代佐剂铺平了道路。在疫苗佐剂设计的框架内，本综述概述了靶向内体和细胞内受体以增强和指导免疫反应的意义。我们介绍并比较了目前备受关注的分子以及潜在的组合。我们强调了靶向适当的受体如何能够将免疫导向适当的反应，例如细胞毒性或黏膜反应。
