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伯基特淋巴瘤细胞中变异型t(2;8)易位的三个断点位于距c-myc基因140千碱基远的一个区域内。

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

作者信息

Henglein B, Synovzik H, Groitl P, Bornkamm G W, Hartl P, Lipp M

机构信息

Institut für medizinische Mikrobiologie und Hygiene, Abteilung Virologie, Freiburg, Federal Republic of Germany.

出版信息

Mol Cell Biol. 1989 May;9(5):2105-13. doi: 10.1128/mcb.9.5.2105-2113.1989.

DOI:10.1128/mcb.9.5.2105-2113.1989
PMID:2747644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363004/
Abstract

The variant translocations t(2;8) in Burkitt's lymphoma cells join band q24 of chromosome 8, distal from c-myc, to the Igkappa locus, with considerable variation in the location of the breakpoints on chromosome 8. We report the cloning and molecular characterization of a chromosome 8 region, distal from the c-myc locus, which encompasses the breakpoints of the Burkitt's lymphoma cell lines BL64, BL21, and LY91 within 11 kilobase pairs, termed provisionally bvr-1 (Burkitt's variants' rearranging region 1). Using probes from the c-myc, the bvr-1, and the human pvt-1 loci obtained by chromosome walking coupled with pulsed-field gel electrophoresis, we have constructed a physical map of the region 3' of c-myc. We map bvr-1 and pvt-1 about 140 and 260 kilobase pairs, respectively, distal from c-myc.

摘要

伯基特淋巴瘤细胞中的变异易位t(2;8)将8号染色体q24带（位于c-myc远端）与免疫球蛋白κ基因座相连，8号染色体上断点的位置存在相当大的差异。我们报告了一个位于c-myc基因座远端的8号染色体区域的克隆及分子特征分析，该区域在11千碱基对内包含伯基特淋巴瘤细胞系BL64、BL21和LY91的断点，暂称为bvr-1（伯基特变异体重排区域1）。利用通过染色体步移结合脉冲场凝胶电泳获得的来自c-myc、bvr-1和人类pvt-1基因座的探针，我们构建了c-myc 3'端区域的物理图谱。我们将bvr-1和pvt-1分别定位在距c-myc约140和260千碱基对的位置。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/e100d0537861/molcellb00053-0309-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/dc8865f64938/molcellb00053-0308-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/0db2d797d6e7/molcellb00053-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/c188c1e54464/molcellb00053-0307-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/e100d0537861/molcellb00053-0309-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/dc8865f64938/molcellb00053-0308-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/0db2d797d6e7/molcellb00053-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/c188c1e54464/molcellb00053-0307-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/363004/e100d0537861/molcellb00053-0309-a.jpg

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本文引用的文献

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Utility of immunohistochemistry with an antibody against MYC at the initial diagnosis of follicular lymphoma, grade 3A, for predicting a more aggressive clinical course: a case report and review of the literature.抗MYC抗体免疫组化在滤泡性淋巴瘤3A级初诊时预测更具侵袭性临床病程的效用：一例病例报告及文献复习
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在人类伯基特淋巴瘤和鼠浆细胞瘤细胞中，c-myc基因易位至免疫球蛋白重链基因座。
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c-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations.c-myc和免疫球蛋白κ轻链恒定基因位于三条带有t(2;8)易位的伯基特淋巴瘤细胞系的8q+染色体上。
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Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.通过脉冲场梯度凝胶电泳分离酵母染色体大小的DNA。
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EBV-positive Burkitt's lymphoma from Algeria, with a three-way rearrangement involving chromosomes 2, 8 and 9.来自阿尔及利亚的EBV阳性伯基特淋巴瘤，伴有涉及2号、8号和9号染色体的三方重排。
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