Kong Y C, Lau C P, Wat K H, Ng K H, But P P, Cheng K F, Waterman P G
Planta Med. 1989 Apr;55(2):176-8. doi: 10.1055/s-2006-961917.
Chloroform extracts of the root, stem and leaf of Ruta graveolens L. showed significant anti-fertility activity in rats when administered intragastrically on days 1-10 post-coitum. Fractionation of the extracts led to the isolation of chalepensin as the active component with some toxicity. Time-dosing experiments demonstrated that chalepensin acts at the early stages of pregnancy. It is not clear at this stage if the anti-fertility effect is a direct manifestation of chalepensin toxicity.
在交配后第1 - 10天经胃内给药时，芸香根、茎和叶的氯仿提取物对大鼠显示出显著的抗生育活性。对提取物进行分馏后分离出了具有一定毒性的活性成分查莱平。时间给药实验表明，查莱平在妊娠早期起作用。现阶段尚不清楚抗生育作用是否是查莱平毒性的直接表现。
