Gandhi M, Lal R, Sankaranarayanan A, Sharma P L
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
J Ethnopharmacol. 1991 Aug;34(1):49-59. doi: 10.1016/0378-8741(91)90188-j.
Different preparations of Ruta graveolens were administered orally to female rats (Days 1-10 post coition) and female hamsters (Days 1-6 post coition). The powdered root (CDR), aerial parts (CDA) and the aerial parts aqueous extract (AEA) all showed potential anticonceptive activity in rats. Limited administration on selected days of CDA showed uniformly lesser activity than with 10-day treatment. Sequentially prepared petroleum ether and methanol extracts of CDA were as active as CDA itself. The benzene and chloroform extracts were toxic and inactive. Rutin, a known chemical constituent of the plant, was found to be inactive. None of the above preparations showed activity in hamsters.
将芸香的不同制剂口服给予雌性大鼠（交配后第1 - 10天）和雌性仓鼠（交配后第1 - 6天）。根粉（CDR）、地上部分（CDA）和地上部分水提取物（AEA）在大鼠中均显示出潜在的抗生育活性。在选定的几天给予CDA，其活性始终低于10天治疗组。依次制备的CDA石油醚提取物和甲醇提取物与CDA本身活性相同。苯提取物和氯仿提取物有毒且无活性。芦丁是该植物的一种已知化学成分，被发现无活性。上述制剂在仓鼠中均未显示出活性。
