Sugiura Tomonori, Dohi Yasuaki, Yamashita Sumiyo, Murai Shunsuke, Ohte Nobuyuki
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601 Japan.
Department of Internal Medicine, Faculty of Rehabilitation Science, Nagoya Gakuin University, Nagoya, Japan.
Thromb J. 2016 Aug 2;14:16. doi: 10.1186/s12959-016-0090-4. eCollection 2016.
Aortic thrombosis is a rare disease and only a few cases of the disease, especially associated with chemotherapy for malignant diseases and/or blood diseases, have been previously reported. Although Virchow's triad for thrombogenesis, namely hypercoagulability, blood flow stasis, and vessel wall injury, is the major factor promoting the formation of thrombosis, the detailed mechanism of the disease has not been well established.
We report a case of aortic thrombosis incidentally detected by computed tomography and then regressed by pharmacotherapy using warfarin. This case is an apparently healthy man in a postoperative state after lung cancer surgery with decreased protein-C activity.
A case of aortic thrombosis without an obvious abnormality of the aorta was incidentally identified. A few cases of aortic thrombosis in healthy aortas have been reported to be associated with chemotherapy or blood diseases, however our present case did not had such a background. Although the detailed mechanism remains to be elucidated, this case suggests that aortic thrombosis can develop in apparently healthy subjects with a history of cancer surgery.
主动脉血栓形成是一种罕见疾病，此前仅有少数病例报道，尤其是与恶性疾病和/或血液疾病的化疗相关的病例。尽管血栓形成的维氏三联征，即高凝状态、血流淤滞和血管壁损伤，是促进血栓形成的主要因素，但该疾病的详细机制尚未完全明确。
我们报告一例通过计算机断层扫描偶然发现的主动脉血栓形成病例，随后使用华法林进行药物治疗后血栓消退。该病例是一名肺癌手术后处于术后状态的看似健康的男性，其蛋白C活性降低。
偶然发现一例主动脉无明显异常的主动脉血栓形成病例。据报道，少数健康主动脉发生的主动脉血栓形成病例与化疗或血液疾病有关，然而我们目前的病例并无此类背景。尽管详细机制仍有待阐明，但该病例表明，有癌症手术史的看似健康的受试者也可能发生主动脉血栓形成。
