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瑞典饮食脂肪摄入量的变化及冠心病死亡率预测:一项模拟研究

Changes in Dietary Fat Intake and Projections for Coronary Heart Disease Mortality in Sweden: A Simulation Study.

作者信息

Björck Lena, Rosengren Annika, Winkvist Anna, Capewell Simon, Adiels Martin, Bandosz Piotr, Critchley Julia, Boman Kurt, Guzman-Castillo Maria, O'Flaherty Martin, Johansson Ingegerd

机构信息

Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.

Institute of Health and Care Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.

出版信息

PLoS One. 2016 Aug 4;11(8):e0160474. doi: 10.1371/journal.pone.0160474. eCollection 2016.

Abstract

OBJECTIVE

In Sweden, previous favourable trends in blood cholesterol levels have recently levelled off or even increased in some age groups since 2003, potentially reflecting changing fashions and attitudes towards dietary saturated fatty acids (SFA). We aimed to examine the potential effect of different SFA intake on future coronary heart disease (CHD) mortality in 2025.

METHODS

We compared the effect on future CHD mortality of two different scenarios for fat intake a) daily SFA intake decreasing to 10 energy percent (E%), and b) daily SFA intake rising to 20 E%. We assumed that there would be moderate improvements in smoking (5%), salt intake (1g/day) and physical inactivity (5% decrease) to continue recent, positive trends.

RESULTS

In the baseline scenario which assumed that recent mortality declines continue, approximately 5,975 CHD deaths might occur in year 2025. Anticipated improvements in smoking, dietary salt intake and physical activity, would result in some 380 (-6.4%) fewer deaths (235 in men and 145 in women). In combination with a mean SFA daily intake of 10 E%, a total of 810 (-14%) fewer deaths would occur in 2025 (535 in men and 275 in women). If the overall consumption of SFA rose to 20 E%, the expected mortality decline would be wiped out and approximately 20 (0.3%) additional deaths might occur.

CONCLUSION

CHD mortality may increase as a result of unfavourable trends in diets rich in saturated fats resulting in increases in blood cholesterol levels. These could cancel out the favourable trends in salt intake, smoking and physical activity.

摘要

目的

在瑞典,自2003年以来,血液胆固醇水平此前的良好趋势最近在一些年龄组中趋于平稳,甚至有所上升,这可能反映了人们对膳食饱和脂肪酸(SFA)的观念和态度正在发生变化。我们旨在研究不同饱和脂肪酸摄入量对2025年未来冠心病(CHD)死亡率的潜在影响。

方法

我们比较了两种不同脂肪摄入情景对未来冠心病死亡率的影响:a)每日饱和脂肪酸摄入量降至10能量百分比(E%),b)每日饱和脂肪酸摄入量升至20 E%。我们假设吸烟(5%)、盐摄入量(每天1克)和缺乏身体活动(降低5%)会有适度改善,以延续近期的积极趋势。

结果

在假设近期死亡率下降趋势持续的基线情景中,2025年可能发生约5975例冠心病死亡。吸烟、膳食盐摄入量和身体活动的预期改善将导致死亡人数减少约380例(-6.4%)(男性减少235例,女性减少145例)。若结合每日平均饱和脂肪酸摄入量为10 E%,2025年死亡总数将减少810例(-14%)(男性减少535例,女性减少275例)。如果饱和脂肪酸的总体摄入量升至20 E%,预期的死亡率下降将被抵消,可能会额外增加约20例(0.3%)死亡。

结论

富含饱和脂肪的饮食出现不利趋势,导致血液胆固醇水平升高,可能会使冠心病死亡率增加。这些不利趋势可能会抵消盐摄入量、吸烟和身体活动方面的有利趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f09/4973910/5e73bf9c91a2/pone.0160474.g001.jpg

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