Sadowski J A, Hood S J, Dallal G E, Garry P J
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.
Am J Clin Nutr. 1989 Jul;50(1):100-8. doi: 10.1093/ajcn/50.1.100.
Fasting plasma phylloquinone concentrations were determined by reverse-phase high-performance liquid chromatography in a population of young (n = 131) and elderly (n = 195) human subjects. The distribution of values was non-Gaussian but was converted to Gaussian form after a logarithmic transformation of the data. The normal range derived from the lognormal distribution was 0.29-2.64 nmol/L (geometric means = 0.87 nmol/L, median = 0.86 nmol/L). Young females had significantly decreased plasma phylloquinone concentrations when compared with the elderly females whereas concentrations in young males were slightly higher than those in elderly males. A regression model was constructed and revealed that plasma phylloquinone concentrations were positively correlated with plasma triglycerides and alpha-tocopherol. Although the elderly subjects (means = 1.05 nmol/L) had higher levels of phylloquinone than the young subjects (0.94 nmol/L), when the concentration of phylloquinone in plasma is expressed as nanomoles phylloquinone per millimole of triglyceride, the elderly subjects (0.62 x 10(-6) showed decreased levels for phylloquinone compared with the young subjects (0.82 x 10(-6) (p less than 0.001).
采用反相高效液相色谱法测定了131名年轻受试者和195名老年受试者群体的空腹血浆叶绿醌浓度。数值分布呈非高斯分布，但在对数据进行对数转换后呈高斯分布形式。从对数正态分布得出的正常范围为0.29 - 2.64 nmol/L（几何平均值 = 0.87 nmol/L，中位数 = 0.86 nmol/L）。与老年女性相比，年轻女性的血浆叶绿醌浓度显著降低，而年轻男性的浓度略高于老年男性。构建了一个回归模型，结果显示血浆叶绿醌浓度与血浆甘油三酯和α - 生育酚呈正相关。尽管老年受试者（平均值 = 1.05 nmol/L）的叶绿醌水平高于年轻受试者（0.94 nmol/L），但当血浆中叶绿醌浓度以每毫摩尔甘油三酯中叶绿醌的纳摩尔数表示时，老年受试者（0.62×10⁻⁶）的叶绿醌水平低于年轻受试者（0.82×10⁻⁶）（p < 0.001）。
