Su Ye, Wu Haijiang, Pavlosky Alexander, Zou Ling-Lin, Deng Xinna, Zhang Zhu-Xu, Jevnikar Anthony M
Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.
Department of Medicine, University of Western Ontario, London, Ontario, Canada.
Cell Death Dis. 2016 Aug 11;7(8):e2333. doi: 10.1038/cddis.2016.210.
Non-coding RNA (ncRNA) comprises a substantial portion of primary transcripts that are generated by genomic transcription, but are not translated into protein. The possible functions of these once considered 'junk' molecules have incited considerable interest and new insights have emerged. The two major members of ncRNAs, namely micro RNA (miRNA) and long non-coding RNA (lncRNA), have important regulatory roles in gene expression and many important physiological processes, which has recently been extended to programmed cell death. The previous paradigm of programmed cell death only by apoptosis has recently expanded to include modalities of regulated necrosis (RN), and particularly necroptosis. However, most research efforts in this field have been on protein regulators, leaving the role of ncRNAs largely unexplored. In this review, we discuss important findings concerning miRNAs and lncRNAs that modulate apoptosis and RN pathways, as well as the miRNA-lncRNA interactions that affect cell death regulation.
非编码RNA（ncRNA）占基因组转录产生的初级转录本的很大一部分，但不翻译成蛋白质。这些曾经被认为是“垃圾”分子的潜在功能引发了人们相当大的兴趣，并且出现了新的见解。ncRNA的两个主要成员，即微小RNA（miRNA）和长链非编码RNA（lncRNA），在基因表达和许多重要生理过程中具有重要的调节作用，最近这一作用已扩展到程序性细胞死亡。以前仅由凋亡介导程序性细胞死亡的模式最近已扩展到包括调节性坏死（RN），特别是坏死性凋亡。然而，该领域的大多数研究工作都集中在蛋白质调节剂上，ncRNA的作用在很大程度上尚未得到探索。在这篇综述中，我们讨论了有关调节凋亡和RN途径的miRNA和lncRNA的重要发现，以及影响细胞死亡调节的miRNA-lncRNA相互作用。
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