El-Heis S, Crozier S R, Robinson S M, Harvey N C, Cooper C, Inskip H M, Godfrey K M
Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Clin Exp Allergy. 2016 Oct;46(10):1337-43. doi: 10.1111/cea.12782. Epub 2016 Sep 15.
Evidence that atopic eczema partly originates in utero is increasing, with some studies linking the risk of developing the condition with aspects of maternal diet during pregnancy. Nicotinamide, a naturally occurring nutrient that is maintained through the dietary intakes of vitamin B3 and tryptophan, has been used in the treatment of some skin conditions including atopic eczema.
To examine the relation of maternal serum concentrations of nicotinamide and related tryptophan metabolites to the risk of atopic eczema in the offspring.
Within the UK Southampton Women Survey, infantile atopic eczema at ages 6 and 12 months was ascertained (modified UK Working Party Criteria for the Definition of Atopic Dermatitis). Maternal serum levels of kynurenine, kynurenic acid, anthranilic acid, tryptophan, nicotinamide and N1-methylnicotinamide were measured in late pregnancy by mass spectrometry (n = 497) and related to the odds ratio of infantile atopic eczema.
Maternal nicotinamide and related metabolite concentrations were not associated with offspring atopic eczema at age 6 months. Higher concentrations of nicotinamide and anthranilic acid were, however, associated with a lower risk of eczema at age 12 months (odds ratios 0.69, 95% CI 0.53-0.91/SD change, P = 0.007 and 0.63, 0.48-0.83, P = 0.001, respectively). The associations were robust to adjustment for potentially confounding variables.
This is the first study linking maternal serum concentrations of nicotinamide and related metabolites to the risk of atopic eczema in the offspring. The findings point to potentially modifiable maternal influences on this complex and highly prevalent condition.
越来越多的证据表明特应性湿疹部分起源于子宫内，一些研究将患该病的风险与孕期母亲饮食的某些方面联系起来。烟酰胺是一种通过维生素B3和色氨酸的饮食摄入而维持的天然营养素，已被用于治疗包括特应性湿疹在内的一些皮肤病。
研究母亲血清中烟酰胺及相关色氨酸代谢产物浓度与后代患特应性湿疹风险之间的关系。
在英国南安普敦妇女调查中，确定了6个月和12个月大婴儿的婴儿期特应性湿疹（采用英国工作组修订的特应性皮炎定义标准）。通过质谱法测量了孕晚期497名母亲血清中犬尿氨酸、犬尿酸、邻氨基苯甲酸、色氨酸、烟酰胺和N1-甲基烟酰胺的水平，并将其与婴儿期特应性湿疹的比值比相关联。
母亲烟酰胺及相关代谢产物浓度与6个月大后代的特应性湿疹无关。然而，烟酰胺和邻氨基苯甲酸浓度较高与12个月大时患湿疹的风险较低相关（比值比分别为0.69，95%可信区间0.53-0.91/标准差变化，P = 0.007；以及0.63，0.48-0.83，P = 0.001）。这些关联在对潜在混杂变量进行调整后仍然稳健。
这是第一项将母亲血清中烟酰胺及相关代谢产物浓度与后代患特应性湿疹风险联系起来的研究。研究结果表明母亲对这种复杂且高度普遍的疾病可能存在可改变的影响。
