Serrano Alejandra, Nogales Fátima, Sobrino Paula, Murillo María Luisa, Carreras Olimpia, Ojeda María Luisa
Department of Physiology, Faculty of Pharmacy, Seville University, Seville, Spain.
Mol Nutr Food Res. 2016 Dec;60(12):2633-2641. doi: 10.1002/mnfr.201600511. Epub 2016 Oct 10.
Cardiac hypertrophy is the greatest complication in metabolic syndrome (MS), in dams and in offspring. The most effective therapies to avoid the evolution of MS are anti-oxidants, anti-inflammatories, and insulin sensitizers. Among anti-oxidant elements, Selenium (Se) exerts its functions through selenoproteins, which are essential for the correct functioning of the cardiovascular system. The aim of the study is analyze selenoproteins' implication in the transmission of future cardiovascular problems to MS progeny.
Heart Se deposits, antioxidant enzymes' activities, biomolecular oxidation, and the expression of selenoproteins, AMPK, and NF-kB were measured in the offspring of dams exposed to a fructose-rich diet (65%) during gestation and lactation, with a normal Se content (0.1 ppm). Thyroid hormones and MCP-1 serum levels, as well as blood pressure and heart rate were also measured. Fructose-exposed pups have cardiomegaly, oxidation, and depletion in Se heart deposits, a decrease in selenoproteins' expression and in the p-AMPK/AMPKt energy ratio; an increase in NF-kB p65 expression, and a decrease of thyroid hormones and MCP-1. Heart rate and blood pressure were altered.
These data indicate that dietary Se supplementation could be an inexpensive therapy for avoiding future cardiovascular complication in the progeny of MS dams.
心脏肥大是代谢综合征（MS）中母鼠及其后代最严重的并发症。避免MS进展的最有效疗法是抗氧化剂、抗炎药和胰岛素增敏剂。在抗氧化元素中，硒（Se）通过硒蛋白发挥其功能，而硒蛋白对于心血管系统的正常运作至关重要。本研究的目的是分析硒蛋白在将未来心血管问题传递给MS后代中的作用。
对孕期和哺乳期暴露于富含果糖饮食（65%）且硒含量正常（0.1 ppm）的母鼠后代，测量其心脏硒沉积、抗氧化酶活性、生物分子氧化以及硒蛋白、AMPK和NF-κB的表达。还测量了甲状腺激素和MCP-1血清水平以及血压和心率。暴露于果糖的幼崽出现心脏肥大、氧化以及心脏硒沉积减少，硒蛋白表达和p-AMPK/AMPKt能量比值降低；NF-κB p65表达增加，甲状腺激素和MCP-1减少。心率和血压发生改变。
这些数据表明，补充膳食硒可能是一种廉价的疗法，可避免MS母鼠后代未来出现心血管并发症。
