Department of Physiology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain.
Department of Physiology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain.
Life Sci. 2019 Sep 15;233:116689. doi: 10.1016/j.lfs.2019.116689. Epub 2019 Jul 23.
Maternal metabolic syndrome during gestation and lactation leads to several Se-status-related metabolic changes in offspring. MS leads to hepatomegaly, liver oxidation, resistance to insulin challenges and selenoptroteins expression upregulation, producing an energy imbalance in hepatocytes. As Se is necessary for correct heart function, Se deposits are depleted and selenoproteins expression downregulated in heart; this depletion being related to cardiovascular damage. Recently, selenoproteins have been directly implicated in the central endocrine regulation of appetite and energy homeostasis.
To obtain information about how Se is involved in regulating endocrine peripheral energy balance during MS process, two experimental groups of dam rats were used: control (Se: 0.1 ppm) and MS (Fructose 65% and Se: 0.1 ppm). At the end of lactation (21d old), the pups' appetite profile, tissular Se deposits and peptides from gastrointestinal tract (including pancreas), leptin, skeletal growth markers and cytokines in serum were measured.
MS-exposed pups present changes in Se homeostasis, appetite profile and endocrine energy balance signals related to impaired insulin secretion and high leptin serum values. This profoundly affects the pups' growth profile since muscle and bones are in catabolic process and brown adipose tissue (BAT) mass decreases.
These results indicate that the pups are suffering a process similar to diabetes type 1 which appeared when dams received low Se dietary supply and they point to Se as an important marker and key treatment for these disorders during gestation and lactation that affect future adult health.
妊娠和哺乳期母体代谢综合征会导致后代出现多种与硒状态相关的代谢变化。MS 会导致肝肿大、氧化、胰岛素抵抗和硒蛋白表达上调，导致肝细胞能量失衡。由于硒对于心脏功能的正常运作是必需的，因此心脏中的硒储备会被耗尽，硒蛋白的表达也会下调；这种耗竭与心血管损伤有关。最近，硒蛋白已被直接牵涉到食欲和能量平衡的中枢内分泌调节中。
为了了解硒在调节代谢综合征过程中如何调节内分泌外周能量平衡，我们使用了两组实验大鼠母鼠：对照组（硒：0.1ppm）和 MS 组（65%果糖和硒：0.1ppm）。在哺乳期结束时（21 天大），测量了幼鼠的食欲特征、组织硒储备以及胃肠道（包括胰腺）中的肽、瘦素、骨骼生长标志物和血清中的细胞因子。
暴露于 MS 的幼鼠出现了硒稳态、食欲特征和与胰岛素分泌受损和高瘦素血清值相关的内分泌能量平衡信号的变化。这会严重影响幼鼠的生长情况，因为肌肉和骨骼处于分解代谢过程中，棕色脂肪组织（BAT）的质量减少。
这些结果表明，幼鼠正在经历一种类似于 1 型糖尿病的过程，这种情况出现在母鼠接受低硒饮食供应时，并指出硒是影响妊娠和哺乳期这些影响未来成年健康的疾病的重要标志物和关键治疗方法。
