Department of Physiology, Faculty of Pharmacy, Seville University, C/Professor García González, nº 2, 41012, Seville, Spain.
Eur J Nutr. 2019 Dec;58(8):3171-3181. doi: 10.1007/s00394-018-1861-4. Epub 2018 Dec 1.
High and low levels of selenium (Se) have been related to metabolic disorders in dams and in their offspring. Their relationship to oxidative balance and to AMP-activated protein kinase (AMPK) is some of the mechanisms proposed. The aim of this study is to acquire information about how Se is involved in metabolic programming.
Three experimental groups of dam rats were used: control (Se: 0.1 ppm), Se supplemented (Se: 0.5 ppm) and Se deficient (Se: 0.01 ppm). At the end of lactation, the pups' metabolic profile, oxidative balance, Se levels, selenoproteins and IRS-1 hepatic expression, as well as hepatic AMPK activation were measured.
The experimental groups present deep changes in Se homeostasis, selenoproteins and IRS-1 hepatic expression, oxidative balance, AMPK activation ratio and insulin levels. They do, however, have different metabolic profiles.
High- and low-Se diets are linked to insulin resistance, yet the mechanisms involved are completely opposite.
高、低硒（Se）水平与母体及其后代的代谢紊乱有关。其与氧化平衡和 AMP 激活蛋白激酶（AMPK）的关系是提出的部分机制。本研究旨在获取有关 Se 如何参与代谢编程的信息。
使用三组实验性母鼠组：对照组（Se：0.1ppm）、补充 Se 组（Se：0.5ppm）和 Se 缺乏组（Se：0.01ppm）。在哺乳期结束时，测量幼鼠的代谢特征、氧化平衡、Se 水平、硒蛋白和 IRS-1 肝表达以及肝 AMPK 激活情况。
实验组的 Se 内稳态、硒蛋白和 IRS-1 肝表达、氧化平衡、AMPK 激活比和胰岛素水平均发生了深刻变化。然而，它们的代谢特征却不同。
高、低 Se 饮食与胰岛素抵抗有关，但涉及的机制却完全相反。
