FOXC1通过激活MST1R/PI3K/AKT促进黑色素瘤的发展。
FOXC1 promotes melanoma by activating MST1R/PI3K/AKT.
作者信息
Wang Jinhua, Li Li, Liu Shiwei, Zhao Ying, Wang Lin, Du Guanhua
机构信息
The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Department of Molecular Oncology, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica 90404, CA, USA.
出版信息
Oncotarget. 2016 Dec 20;7(51):84375-84387. doi: 10.18632/oncotarget.11224.
FOXC1 is a member of Forkhead box family transcription factors. We showed that FOXC1 level was increased in melanoma cells and tissues and correlated with hypomethylation of the FOXC1 gene. Overexpression of FOXC1 promoted proliferation, migration, invasion, colony formation and growth in 3D Matrigel of melanoma cells. FOXC1 increased MST1R and activated the PI3K/AKT pathway. Also, FOXC1 expression was associated with disease progression and poor prognosis of melanoma. We suggest that FOXC1 is a potential prognostic biomarker for treating melanoma and predicting outcome of patients.
FOXC1是叉头框家族转录因子的成员之一。我们发现，黑色素瘤细胞和组织中FOXC1水平升高，且与FOXC1基因的低甲基化相关。FOXC1的过表达促进了黑色素瘤细胞的增殖、迁移、侵袭、集落形成以及在三维基质胶中的生长。FOXC1增加了MST1R的表达并激活了PI3K/AKT信号通路。此外，FOXC1的表达与黑色素瘤的疾病进展和不良预后相关。我们认为，FOXC1是治疗黑色素瘤和预测患者预后的潜在生物标志物。
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