Lu Jun, Gu Yuying, Guo Meixiang, Chen Peihong, Wang Hongtao, Yu Xuemei
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, 6600 Nanfeng Road, Shanghai 201499, China.
Department of Mathematics, Shanghai Business School, 2271 West Zhongshan Road, Shanghai 200235, China.
J Diabetes Res. 2016;2016:1260141. doi: 10.1155/2016/1260141. Epub 2016 Jul 31.
Aim. To investigate the association between serum magnesium levels and microvascular complications among patients with diabetes. Methods. Patients with diabetes were recruited between April 2012 and January 2015. All patients received an assay of serum magnesium concentration, were screened for 24 h albumin excretion rate, and underwent nonmydriatic fundus photography. Albuminuria and retinopathy were defined accordingly. A total of 3,100 patients with normal serum magnesium levels were included in this study. Results. Patients with albuminuria and/or retinopathy had lower levels of serum magnesium than patients without these complications (P < 0.001). The prevalence of isolated albuminuria, isolated retinopathy, and combined albuminuria and retinopathy decreased as the concentration of serum magnesium increased. Multiple logistic regression analysis indicated that the odds ratio for isolated albuminuria, isolated retinopathy, and concomitant albuminuria and retinopathy decreased by approximately 20% for every 0.1 mmol/L increase in serum magnesium concentration. Conclusion. Serum magnesium levels were negatively associated with the risk of diabetic microvascular complications among patients with serum magnesium levels within the normal range.
目的。探讨糖尿病患者血清镁水平与微血管并发症之间的关联。方法。于2012年4月至2015年1月招募糖尿病患者。所有患者均接受血清镁浓度检测，筛查24小时尿白蛋白排泄率，并进行免散瞳眼底照相。据此定义蛋白尿和视网膜病变。本研究共纳入3100例血清镁水平正常的患者。结果。有蛋白尿和/或视网膜病变的患者血清镁水平低于无这些并发症的患者（P<0.001）。随着血清镁浓度升高，单纯蛋白尿、单纯视网膜病变以及蛋白尿合并视网膜病变的患病率降低。多因素logistic回归分析表明，血清镁浓度每升高0.1 mmol/L，单纯蛋白尿、单纯视网膜病变以及蛋白尿合并视网膜病变的比值比下降约20%。结论。在血清镁水平处于正常范围的糖尿病患者中，血清镁水平与糖尿病微血管并发症风险呈负相关。
