de Oliveira Ana Raquel Soares, Cruz Kyria Jayanne Clímaco, Morais Jennifer Beatriz Silva, Severo Juliana Soares, de Freitas Taynáh Emannuelle Coelho, Veras Antonio Lobão, da Rocha Romero Amanda Batista, Colli Célia, do Nascimento Nogueira Nadir, Torres-Leal Francisco Leonardo, do Nascimento Marreiro Dilina
Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil.
Clinical Pathology Laboratory Antonio Lobão, Teresina, Piauí, Brazil.
Biol Trace Elem Res. 2015 Dec;168(2):296-302. doi: 10.1007/s12011-015-0358-8. Epub 2015 May 17.
This study assessed the relationship between magnesium status and C-reactive protein concentration in obese and nonobese women. This cross-sectional study included 131 women, aged between 20 and 50 years, who were divided into two groups: obese (n=65) and control (n=66) groups. Magnesium intake was monitored using 3-day food records and NutWin software version 1.5. The plasma, erythrocyte, and urinary magnesium concentrations were determined by flame atomic absorption spectrophotometry. C-reactive protein concentration in serum was measured by immunoturbidimetric assay. The mean values of the magnesium content in the diet were lower than those recommended, though there was no significant difference between groups (p>0.05). The mean concentrations of plasma and erythrocyte magnesium were within the normal range, with no significant difference between groups (p>0.05). Urinary excretion of this mineral was less than the reference values in both groups, with no significant difference (p>0.05). The mean concentration of serum C-reactive protein was within the normal range in both groups, with no significant difference (p>0.05). There was a positive correlation between urinary magnesium and serum C-reactive protein (p=0.015). Obese patients ingest low dietary magnesium content, which seems to induce hypomagnesuria as a compensatory mechanism to keep plasma concentrations of the mineral at adequate levels. The study shows a positive correlation between urinary magnesium concentrations and serum C-reactive protein, suggesting the influence of hypomagnesuria on this inflammatory protein in obese women.
本研究评估了肥胖和非肥胖女性体内镁水平与C反应蛋白浓度之间的关系。这项横断面研究纳入了131名年龄在20至50岁之间的女性，她们被分为两组：肥胖组（n = 65）和对照组（n = 66）。通过3天的饮食记录和NutWin软件1.5版本监测镁的摄入量。采用火焰原子吸收分光光度法测定血浆、红细胞和尿液中的镁浓度。采用免疫比浊法测定血清中的C反应蛋白浓度。饮食中镁含量的平均值低于推荐值，尽管两组之间无显著差异（p>0.05）。血浆和红细胞镁的平均浓度在正常范围内，两组之间无显著差异（p>0.05）。两组中该矿物质的尿排泄量均低于参考值，无显著差异（p>0.05）。两组血清C反应蛋白的平均浓度均在正常范围内，无显著差异（p>0.05）。尿镁与血清C反应蛋白之间存在正相关（p = 0.015）。肥胖患者摄入的饮食中镁含量较低，这似乎会引发低镁尿症，作为一种将该矿物质血浆浓度维持在适当水平的代偿机制。该研究表明尿镁浓度与血清C反应蛋白之间存在正相关，提示低镁尿症对肥胖女性体内这种炎症蛋白有影响。
