Sönmezgöz Ergün, Ozer Samet, Yilmaz Resul, Önder Yalçın, Bütün Ilknur, Bilge Serap
Rev Med Chil. 2016 May;144(5):611-6. doi: 10.4067/S0034-98872016000500009.
Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases.
To measure vitamin D levels in children with Hashimotos thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls.
We included 68 children with HT aged 12 ± 4 years (39 females) from a pediatric outpatient clinic and 68 healthy children aged 10 ± 4 years (37 females). Calcium metabolism parameters, thyroid function tests and anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and 25 hydroxy vitamin D (25OHD) levels were measured.
Patients were older than controls but well matched by gender distribution. Mean 25OHD levels were significantly lower in HT patients than controls (16.8 ± 9.3 and 24.1 ± 9.4 ng/mL respectively, P < 0.01). Frequency of vitamin D deficiency was 76 and 35% in HT patients and controls, respectively (P < 0.001).
Vitamin D deficiency is more common in children with HT than healthy controls.
维生素D缺乏或不足可能在某些自身免疫性疾病的发病机制中起作用。
测定患有桥本甲状腺炎（HT）（亚临床或明显甲状腺功能减退）的儿童及健康对照儿童的维生素D水平。
我们纳入了来自儿科门诊的68名12±4岁的HT儿童（39名女性）和68名10±4岁的健康儿童（37名女性）。测量了钙代谢参数、甲状腺功能测试以及抗甲状腺过氧化物酶（抗-TPO）、抗甲状腺球蛋白（抗-TG）和25羟维生素D（25OHD）水平。
患者年龄大于对照，但性别分布匹配。HT患者的平均25OHD水平显著低于对照（分别为16.8±9.3和24.1±9.4 ng/mL，P<0.01）。HT患者和对照中维生素D缺乏的频率分别为76%和35%（P<0.001）。
HT儿童中维生素D缺乏比健康对照更常见。
