Holloway Ian W, Dougherty Ryan, Gildner Jennifer, Beougher Sean C, Pulsipher Craig, Montoya Jorge A, Plant Aaron, Leibowitz Arleen
*Department of Social Welfare, Luskin School of Public Affairs, University of California, Los Angeles, CA; †AIDS Project Los Angeles, Los Angeles, CA; and ‡Sentient Research, Los Angeles, CA.
J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):15-20. doi: 10.1097/QAI.0000000000001164.
We investigated pre-exposure prophylaxis (PrEP) uptake, adherence, and discontinuation among young app-using men who have sex with men in California (N = 761). Approximately, 9.7% of participants had ever used PrEP; 87% of those deemed good candidates for screening (indicated by a Centers for Disease Control and Prevention risk index score ≥10) were not current or past users. PrEP use was associated with higher income [adjusted odds ratio (aOR): 4.13; confidence interval (CI): 1.87 to 9.12], receptive condomless anal sex (aOR: 3.41; CI: 1.71 to 6.78), HIV-positive sex partners (aOR: 2.87; CI: 1.53 to 5.38), popper use (aOR: 3.47; CI: 1.96 to 6.13), and recent sexually transmitted infection diagnosis (aOR: 2.90; CI: 1.64 to 5.13). Some users (41.5%) wanted help remembering to take PrEP. The top reason for discontinuation was concern about long-term side effects (33.0%). Young men who have sex with men app users are prime candidates for PrEP, despite low uptake. Apps may be useful tools for PrEP information dissemination, adherence monitoring, and support.
我们调查了加利福尼亚州使用应用程序的男男性行为年轻人群（N = 761）的暴露前预防（PrEP）使用情况、依从性和停药情况。约9.7%的参与者曾使用过PrEP；在那些被认为是筛查良好候选者（由疾病控制和预防中心风险指数得分≥10表明）中，87%不是当前或过去的使用者。PrEP的使用与较高收入相关[调整优势比（aOR）：4.13；置信区间（CI）：1.87至9.12]、无保护肛交性行为（aOR：3.41；CI：1.71至6.78）、HIV阳性性伴侣（aOR：2.87；CI：1.53至5.38）、使用Poppers（aOR：3.47；CI：1.96至6.13）以及近期性传播感染诊断（aOR：2.90；CI：1.64至5.13）有关。一些使用者（41.5%）希望得到帮助以记住服用PrEP。停药的首要原因是对长期副作用的担忧（33.0%）。尽管PrEP使用率较低，但使用应用程序的男男性行为年轻人群是PrEP的主要候选对象。应用程序可能是PrEP信息传播、依从性监测和支持的有用工具。
