O'Neill Catherine A, Monteleone Giovanni, McLaughlin John T, Paus Ralf
Dermatology Research Centre, Institute of Inflammation and Repair, University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.
Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Bioessays. 2016 Nov;38(11):1167-1176. doi: 10.1002/bies.201600008. Epub 2016 Aug 24.
As crucial interface organs gut and skin have much in common. Therefore it is unsurprising that several gut pathologies have skin co-morbidities. Nevertheless, the reason for this remains ill explored, and neither mainstream gastroenterology nor dermatology research have systematically investigated the 'gut-skin axis'. Here, in reviewing the field, we propose several mechanistic levels on which gut and skin may interact under physiological and pathological circumstances. We focus on the gut microbiota, with its huge metabolic capacity, and the role of dietary components as potential principle actors along the gut-skin axis. We suggest that metabolites from either the diet or the microbiota are skin accessible. After defining open key questions around the nature of these metabolites, how they are sensed, and which cutaneous changes they can induce, we propose that understanding of these pathways will lead to novel therapeutic strategies based on targeting one organ to improve the health of the other.
作为关键的界面器官，肠道和皮肤有许多共同之处。因此，几种肠道疾病伴有皮肤共病并不奇怪。然而，其原因仍未得到充分探索，主流胃肠病学和皮肤病学研究都未系统地研究“肠-皮轴”。在此，在回顾该领域时，我们提出了几个机制层面，在生理和病理情况下，肠道和皮肤可能在这些层面上相互作用。我们关注具有巨大代谢能力的肠道微生物群，以及饮食成分作为肠-皮轴潜在主要作用因素的作用。我们认为，来自饮食或微生物群的代谢产物可到达皮肤。在确定了围绕这些代谢产物的性质、它们如何被感知以及它们能诱导哪些皮肤变化的关键开放性问题后，我们提出，对这些途径的理解将带来基于靶向一个器官以改善另一个器官健康的新型治疗策略。
