CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, France.
INSERM, U1191, Montpellier, France.
Mucosal Immunol. 2016 Nov;9(6):1353-1359. doi: 10.1038/mi.2016.68. Epub 2016 Aug 24.
Epithelial tuft cells (also known as "brush" cells in the airway) were first identified morphologically, almost six decades ago in the trachea and gastro-intestinal tract, but their function remained mysterious until three almost simultaneous reports recently revealed their essential role in the initiation of immune type 2 responses. This is a new and exciting example of cooperation between the epithelial and haematopoietic compartments for the management of enteric parasite infections. Here we review tuft cell functions and markers, and anchors epithelial tuft cells within the current paradigm of type 2 immune responses.
上皮簇状细胞（在气道中也被称为“刷状”细胞）在大约六十年前首先在气管和胃肠道中从形态学上被识别出来，但它们的功能一直很神秘，直到最近三项几乎同时的报告揭示了它们在启动免疫 2 型反应中的重要作用。这是上皮细胞和造血细胞之间为了管理肠道寄生虫感染而进行合作的一个新的令人兴奋的例子。在这里，我们回顾了簇状细胞的功能和标记物，并将上皮簇状细胞置于 2 型免疫反应的当前范例中。
