Wang Shan, Xu Xin, Xu Fei, Meng Yan, Sun Changsheng, Shi Lei, Zhao Eryang
a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
b Department of Oral Medicine , Heilongjiang Nursing College , Harbin , China.
Cancer Invest. 2016 Sep 13;34(8):393-400. doi: 10.1080/07357907.2016.1217422. Epub 2016 Aug 24.
To identify the prognostic value of c-jun, c-fos, and p53 in oral cancer, we examined the impact of immunohistochemical expression of these markers on tumor progression in 157 oral squamous cell carcinoma (OSCC). We found that c-jun or c-fos was significantly associated with lymph node metastasis, and coexpression of c-jun/c-fos, or c-jun/c-fos/p53 were significantly associated with lymph node metastasis, poor differentiation and clinical stage. The coexpression of c-jun/c-fos/p53 was identified as independent prognostic factors for overall survival. Simultaneous coexpression of these markers in OSCCs might prove to be a useful indicator for differentiation of low and high-risk patients.
为了确定c-jun、c-fos和p53在口腔癌中的预后价值，我们检测了这三种标志物的免疫组化表达对157例口腔鳞状细胞癌（OSCC）肿瘤进展的影响。我们发现，c-jun或c-fos与淋巴结转移显著相关，c-jun/c-fos或c-jun/c-fos/p53的共表达与淋巴结转移、低分化及临床分期显著相关。c-jun/c-fos/p53的共表达被确定为总生存期的独立预后因素。这些标志物在OSCC中的同时共表达可能是区分低风险和高风险患者的有用指标。
