Pap A, Boros L
First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Pancreas. 1989;4(2):249-55. doi: 10.1097/00006676-198904000-00015.
Chronic obstructive pancreatitis-like histological and biochemical alterations were provoked in male Wistar rats with Ethibloc occlusion of the common bile duct and the main pancreatic ducts. After the disappearance of the glue from the ducts, a gradual and almost total recovery was demonstrated during a 2-month observation period. About 12 g/kg of alcohol (20% vol/vol) given daily by gastric intubation and ad libitum intake inhibited the recovery of pancreatic weight and enzyme contents in the occluded rats, and within a 2-month period chronic calcifying-type pancreatitis became evident with some signs of remaining obstructive pancreatitis-like lesions. Cessation of alcohol administration after 2 months resulted in a recovery of pancreatic weight and enzyme contents, although morphological regeneration was less pronounced and calcification remained visible in some rats. A 50% raw soy flour diet provoked some further changes in the proportion of enzymes without any supplementary increases of pancreatic weight and protein content. This animal model of chronic pancreatitis demonstrates that chronic obstructive and calcifying pancreatitis can appear together and earlier if the etiological factors act in combination. Suppression of pancreatic regeneration by alcohol seems to be necessary to maintain chronic pancreatitis-like lesions and to develop calcification.
通过用Ethibloc阻塞雄性Wistar大鼠的胆总管和主胰管，诱发了类似慢性阻塞性胰腺炎的组织学和生化改变。导管中的胶水消失后，在2个月的观察期内显示出逐渐且几乎完全的恢复。通过胃管每日给予约12 g/kg酒精（20%体积/体积）并随意摄入，抑制了阻塞大鼠胰腺重量和酶含量的恢复，并且在2个月内，慢性钙化型胰腺炎变得明显，伴有一些残留的类似阻塞性胰腺炎病变的迹象。2个月后停止给予酒精，胰腺重量和酶含量有所恢复，尽管形态学再生不太明显，并且在一些大鼠中仍可见钙化。50%的生大豆粉饮食在不增加胰腺重量和蛋白质含量的情况下，使酶的比例发生了一些进一步的变化。这种慢性胰腺炎动物模型表明，如果病因因素共同作用，慢性阻塞性和钙化性胰腺炎可能同时出现且更早出现。酒精对胰腺再生的抑制似乎是维持类似慢性胰腺炎病变和形成钙化所必需的。
