Rabin B M, Hunt W A, Joseph J A
Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20814-5145.
Radiat Res. 1989 Jul;119(1):113-22.
Conditioned taste aversion was used to evaluate the behavioral toxicity of exposure to high-energy iron particles (56Fe, 600 MeV/amu) in comparison to that of gamma photons (60Co), high-energy electrons, or fission neutrons. Exposure to high-energy iron particles (5-500 cGy) produced a dose-dependent taste aversion with a maximal effect achieved with a dose of 30 cGy. Gamma photons and electrons were the least effective stimuli for producing a conditioned taste aversion, with a maximal aversion obtained only after exposure to 500 cGy, while the effectiveness of fission neutrons was intermediate to that of photons and iron particles, and a maximal aversion was obtained with a dose of 100 cGy. In the second experiment, rats with lesions of the area postrema were exposed to iron particles (30 cGy), but failed to acquire a taste aversion. The results indicate that (1) high-energy iron particles are more toxic than other qualities of radiation and (2) similar mechanisms mediate the behavioral toxicity of gamma photons and high-energy iron particles.
采用条件性味觉厌恶来评估暴露于高能铁粒子（56Fe，600 MeV/amu）与γ光子（60Co）、高能电子或裂变中子相比的行为毒性。暴露于高能铁粒子（5 - 500 cGy）会产生剂量依赖性味觉厌恶，在30 cGy剂量时达到最大效应。γ光子和电子是产生条件性味觉厌恶最无效的刺激因素，仅在暴露于500 cGy后才获得最大厌恶反应，而裂变中子的有效性介于光子和铁粒子之间，在100 cGy剂量时获得最大厌恶反应。在第二个实验中，延髓后区受损的大鼠暴露于铁粒子（30 cGy），但未能产生味觉厌恶。结果表明：（1）高能铁粒子比其他辐射性质更具毒性；（2）类似机制介导γ光子和高能铁粒子的行为毒性。
