• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy.

作者信息

Mao Li, Liu Chenglin, Wang Zhen, Niu Xiaofeng, Xue Liang, Zhou Zhilei, Cai Zhenying, Yu Meng, Li Yixue, Wu Dianqing, Li Lin

机构信息

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai 200031, China.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

出版信息

Cell Res. 2016 Sep;26(9):1067-70. doi: 10.1038/cr.2016.97. Epub 2016 Aug 26.

DOI:10.1038/cr.2016.97
PMID:27561817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5034115/
Abstract
摘要

相似文献

1
A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy.一种用于最小化由功能冗余导致的假阴性的全基因组功能丧失筛选方法。
Cell Res. 2016 Sep;26(9):1067-70. doi: 10.1038/cr.2016.97. Epub 2016 Aug 26.
2
An effective method for controlling false discovery and false nondiscovery rates in genome-scale RNAi screens.一种在全基因组RNA干扰筛选中控制错误发现率和错误未发现率的有效方法。
J Biomol Screen. 2010 Oct;15(9):1116-22. doi: 10.1177/1087057110381783. Epub 2010 Sep 20.
3
The use of SSMD-based false discovery and false nondiscovery rates in genome-scale RNAi screens.基于单样本多重检验发现率的错误发现率和错误非发现率在基因组规模RNA干扰筛选中的应用
J Biomol Screen. 2010 Oct;15(9):1123-31. doi: 10.1177/1087057110381919. Epub 2010 Sep 17.
4
Indirubin-3'-oxime reverses bone loss in ovariectomized and hindlimb-unloaded mice via activation of the Wnt/β-catenin signaling.靛玉红-3'-肟通过激活Wnt/β-连环蛋白信号通路逆转去卵巢和后肢卸载小鼠的骨质流失。
J Bone Miner Res. 2014;29(5):1196-205. doi: 10.1002/jbmr.2147.
5
False-negative results in screening programmes: systematic review of impact and implications.筛查项目中的假阴性结果：影响与意义的系统评价
Health Technol Assess. 2000;4(5):1-120.
6
Kinetics of Wnt-driven beta-catenin stabilization revealed by quantitative and temporal imaging.通过定量和时间成像揭示Wnt驱动的β-连环蛋白稳定的动力学
PLoS One. 2008;3(10):e3498. doi: 10.1371/journal.pone.0003498. Epub 2008 Oct 22.
7
Indirubin-3'-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice.靛玉红-3'-肟，一种Wnt/β-连环蛋白信号通路的激活剂，可增强ST2细胞的成骨能力，并恢复高脂饮食诱导的肥胖雄性小鼠的骨质流失。
Bone. 2014 Aug;65:60-8. doi: 10.1016/j.bone.2014.05.003. Epub 2014 May 9.
8
Previous imaging findings of breast cancers that occurred in combined screening negatives.联合筛查阴性中发生的乳腺癌的先前影像学发现。
Eur J Radiol. 2010 Jul;75(1):e22-8. doi: 10.1016/j.ejrad.2009.06.015. Epub 2009 Jul 19.
9
A method with flexible and balanced control of false negatives and false positives for hit selection in RNA interference high-throughput screening assays: a statistical terminology.一种在RNA干扰高通量筛选试验中用于命中选择的对假阴性和假阳性进行灵活且平衡控制的方法：一种统计术语。
J Biomol Screen. 2008 Apr;13(4):309-11. doi: 10.1177/1087057108316314.
10
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.解析经典Wnt信号在发育和疾病中的功能：小鼠中β-连环蛋白的条件性功能丧失和功能获得突变
Genes Dev. 2008 Sep 1;22(17):2308-41. doi: 10.1101/gad.1686208.

引用本文的文献

1
Oncogenic and Circadian Effects of Small Molecules Directly and Indirectly Targeting the Core Circadian Clock.小分子直接和间接靶向核心生物钟的致癌和昼夜节律效应。
Integr Cancer Ther. 2020 Jan-Dec;19:1534735420924094. doi: 10.1177/1534735420924094.
2
The plant sesquiterpene lactone parthenolide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1.植物倍半萜内酯中的小白菊内酯通过阻断转录调节因子 TCF4/LEF1 的合成来抑制 Wnt/β-catenin 信号通路。
J Biol Chem. 2018 Apr 6;293(14):5335-5344. doi: 10.1074/jbc.M117.819300. Epub 2018 Feb 9.

本文引用的文献

1
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.USP6致癌基因通过去泛素化卷曲蛋白来促进Wnt信号传导。
Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2945-54. doi: 10.1073/pnas.1605691113. Epub 2016 May 9.
2
Applications of RNA interference high-throughput screening technology in cancer biology and virology.RNA干扰高通量筛选技术在癌症生物学和病毒学中的应用。
Protein Cell. 2014 Nov;5(11):805-15. doi: 10.1007/s13238-014-0076-6. Epub 2014 Jun 22.
3
FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.FAM129B是黑色素瘤细胞中Wnt/β-连环蛋白信号转导的新型调节因子。
F1000Res. 2013 May 31;2:134. doi: 10.12688/f1000research.2-134.v2. eCollection 2013.
4
Database resources of the National Center for Biotechnology Information.国家生物技术信息中心数据库资源。
Nucleic Acids Res. 2014 Jan;42(Database issue):D7-17. doi: 10.1093/nar/gkt1146. Epub 2013 Nov 19.
5
Genetic redundancies and their evolutionary maintenance.遗传冗余及其进化维持。
Adv Exp Med Biol. 2012;751:279-300. doi: 10.1007/978-1-4614-3567-9_13.
6
Wnt/β-catenin signaling and disease.Wnt/β-连环蛋白信号通路与疾病
Cell. 2012 Jun 8;149(6):1192-205. doi: 10.1016/j.cell.2012.05.012.
7
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.在正常心脏流出道、耳蜗和神经管发育过程中，小鼠的散乱蛋白3与散乱蛋白1和2在冗余途径中发挥作用。
PLoS Genet. 2008 Nov;4(11):e1000259. doi: 10.1371/journal.pgen.1000259. Epub 2008 Nov 14.
8
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.一项针对Wnt/β-连环蛋白信号通路成分的全基因组RNA干扰筛选，确定了TCF转录因子在癌症中意想不到的作用。
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9697-702. doi: 10.1073/pnas.0804709105. Epub 2008 Jul 10.
9
Clustal W and Clustal X version 2.0.Clustal W和Clustal X 2.0版本
Bioinformatics. 2007 Nov 1;23(21):2947-8. doi: 10.1093/bioinformatics/btm404. Epub 2007 Sep 10.
10
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.利用一系列等位基因胚胎干细胞系显示GSK-3α和GSK-3β在Wnt/β-连环蛋白信号通路中的功能冗余。
Dev Cell. 2007 Jun;12(6):957-71. doi: 10.1016/j.devcel.2007.04.001.