用于结肠癌有效光热治疗的纳米级聚合物金属有机框架杂化物。
Nanoscale Polymer Metal-Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers.
机构信息
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin, 130022, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
出版信息
Adv Mater. 2016 Nov;28(42):9320-9325. doi: 10.1002/adma.201602997. Epub 2016 Aug 30.
A UiO-66 core with various sizes acts as heterogeneous nucleation center and enables aniline polymerization under ambient conditions. The as-synthesized UiO-66@PAN possesses uniform size and excellent dispersibility in aqueous solution. UiO-66@PAN can be internalized by cancer cells via endocytosis, and indicates significant photothermal therapeutic effect in vitro, and can effectively inhibit the growth of colon cancers in vivo.
UiO-66 核具有各种不同的尺寸，可作为非均相成核中心，并能在环境条件下引发苯胺聚合。所合成的 UiO-66@PAN 具有均匀的尺寸和在水溶液中的良好分散性。UiO-66@PAN 可通过胞吞作用被癌细胞内化，并在体外显示出显著的光热治疗效果，能有效地抑制体内结肠癌的生长。
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