Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch and Shriners Burns Hospital, 301 University Boulevard, Galveston, TX 77555-0165 USA.
Burns Trauma. 2016 Aug 10;4:29. doi: 10.1186/s41038-016-0056-6. eCollection 2016.
Given that oxidative stress is an inherent response to burn injury, it is puzzling as to why investigation into anti-oxidant therapy as an adjunct to burn treatment has been limited. Both the inflammatory response and the stress response to burn injury involve oxidative stress, and there has been some limited success in studies using gamma tocopherol and selenium to improve certain consequences of burns. Much remains to be done to investigate the number, doses and combinations of anti-oxidants, their efficacy, and limitations in improving defined outcomes after burn injury.
鉴于氧化应激是烧伤损伤的固有反应，令人费解的是，为什么对抗氧化剂治疗作为烧伤治疗的辅助手段的研究受到限制。烧伤损伤的炎症反应和应激反应都涉及氧化应激，使用γ-生育酚和硒来改善烧伤的某些后果已经取得了一些有限的成功。仍有许多工作要做，以研究抗氧化剂的数量、剂量和组合，评估其在改善烧伤后特定结局方面的疗效和局限性。
