Teponno Rémy Bertrand, Tanaka Chiaki, Jie Bai, Tapondjou Léon Azefack, Miyamoto Tomofumi
Department of Chemistry, Faculty of Science, University of Dschang.
Chem Pharm Bull (Tokyo). 2016;64(9):1347-55. doi: 10.1248/cpb.c16-00337.
Four previously unreported steroidal saponins, trifasciatosides A-D (1-4), three pairs of previously undescribed steroidal saponins, trifasciatosides E-J (5a, b-7a, b) including acetylated ones, together with twelve known compounds were isolated from the n-butanol soluble fraction of the methanol extract of Sansevieria trifasciata. Their structures were elucidated on the basis of detailed spectroscopic analysis, including (1)H-NMR, (13)C-NMR, (1)H-(1)H correlated spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC), total correlated spectroscopy (TOCSY), nuclear Overhauser enhancement and exchange spectroscopy (NOESY), electrospray ionization-time of flight (ESI-TOF)-MS and chemical methods. Compounds 2, 4, and 7a, b exhibited moderate antiproliferative activity against HeLa cells.
从虎尾兰甲醇提取物的正丁醇可溶部分中分离出4个未见报道的甾体皂苷,即三色虎尾兰皂苷A-D(1-4),3对未见报道的甾体皂苷,即三色虎尾兰皂苷E-J(5a,b-7a,b)(包括乙酰化产物),以及12个已知化合物。通过详细的光谱分析,包括(1)H-NMR、(13)C-NMR、(1)H-(1)H相关光谱(COSY)、异核单量子相干(HSQC)、异核多键连接(HMBC)、全相关光谱(TOCSY)、核Overhauser增强和交换光谱(NOESY)、电喷雾电离飞行时间(ESI-TOF)-MS以及化学方法,阐明了它们的结构。化合物2、4和7a、b对HeLa细胞表现出中等程度的抗增殖活性。