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三尖杉皂苷A-J,来自虎尾兰的甾体皂苷

Trifasciatosides A-J, Steroidal Saponins from Sansevieria trifasciata.

作者信息

Teponno Rémy Bertrand, Tanaka Chiaki, Jie Bai, Tapondjou Léon Azefack, Miyamoto Tomofumi

机构信息

Department of Chemistry, Faculty of Science, University of Dschang.

出版信息

Chem Pharm Bull (Tokyo). 2016;64(9):1347-55. doi: 10.1248/cpb.c16-00337.

Abstract

Four previously unreported steroidal saponins, trifasciatosides A-D (1-4), three pairs of previously undescribed steroidal saponins, trifasciatosides E-J (5a, b-7a, b) including acetylated ones, together with twelve known compounds were isolated from the n-butanol soluble fraction of the methanol extract of Sansevieria trifasciata. Their structures were elucidated on the basis of detailed spectroscopic analysis, including (1)H-NMR, (13)C-NMR, (1)H-(1)H correlated spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC), total correlated spectroscopy (TOCSY), nuclear Overhauser enhancement and exchange spectroscopy (NOESY), electrospray ionization-time of flight (ESI-TOF)-MS and chemical methods. Compounds 2, 4, and 7a, b exhibited moderate antiproliferative activity against HeLa cells.

摘要

从虎尾兰甲醇提取物的正丁醇可溶部分中分离出4个未见报道的甾体皂苷,即三色虎尾兰皂苷A-D(1-4),3对未见报道的甾体皂苷,即三色虎尾兰皂苷E-J(5a,b-7a,b)(包括乙酰化产物),以及12个已知化合物。通过详细的光谱分析,包括(1)H-NMR、(13)C-NMR、(1)H-(1)H相关光谱(COSY)、异核单量子相干(HSQC)、异核多键连接(HMBC)、全相关光谱(TOCSY)、核Overhauser增强和交换光谱(NOESY)、电喷雾电离飞行时间(ESI-TOF)-MS以及化学方法,阐明了它们的结构。化合物2、4和7a、b对HeLa细胞表现出中等程度的抗增殖活性。

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