Gonçalves R, Valente C, Ferreira E, Serra J E, da Cunha J Saraiva
Infectious Diseases Unit - Centro Hospitalar e Universitário de Coimbra (Coimbrás Hospital Centre and University), Coimbra, Portugal.
IDCases. 2016 Aug 11;5:83-4. doi: 10.1016/j.idcr.2016.08.001. eCollection 2016.
Cytomegalovirus is a double stranded DNA virus that can be present in nearly all organs and body fluids. The primary infection is usually asymptomatic in the immunocompetent host and it is common among adolescents and young adults. The symptomatic form appears, in the majority of cases, as a mononucleosis syndrome with full recovery without specific treatment. We report a case of a 25 years old woman who presented with hepatitis due to CMV infection and history of omalizumab administration one month earlier. This recombinant monoclonal antibody is used to control refractory asthma and chronic spontaneous urticarial as it inhibits human IgE. Despite that, the long course of the disease lead us to initiate treatment with valganciclovir. The improvement after that was rapid and complete.
巨细胞病毒是一种双链DNA病毒，几乎可存在于所有器官和体液中。在免疫功能正常的宿主中，原发性感染通常无症状，在青少年和年轻人中很常见。在大多数情况下，症状性形式表现为单核细胞增多症综合征，无需特殊治疗即可完全康复。我们报告一例25岁女性病例，该患者因巨细胞病毒感染出现肝炎，且一个月前有奥马珠单抗用药史。这种重组单克隆抗体用于控制难治性哮喘和慢性自发性荨麻疹，因为它可抑制人IgE。尽管如此，疾病的漫长病程促使我们开始使用缬更昔洛韦进行治疗。此后病情迅速且完全好转。
