Rácz O, Kuzmová D, Futás E, Kollár J, Vícha T, Reiter G
Cas Lek Cesk. 1989 Jun 2;128(23):714-7.
Using a mathematical model, the authors analyze the relationship between glycemia and glycated haemoglobin concentration (GHb). This relationship is more complex that it seems at first sight as GHb concentration in erythrocytes is the outcome of two processes: glucose binding to haemoglobin and continuous turnover of erythrocytes in blood. Old erythrocytes carry information on glycemia of longer duration than do the younger ones. The result is that hyperglycemias which occurred immediately before to GHb estimation have a greater effect on GHb concentration than those that occurred former. Due to the fact that behind a certain value of GHb different hyperglycemic periods can be hidden, the compensation of a patient with diabetes mellitus cannot be assessed only on the basis of GHb concentration. The assessment can only be made when using criteria which take into consideration glycemia, glycated plasmatic protein, and glycated haemoglobin values in a complex way.
作者使用数学模型分析血糖与糖化血红蛋白浓度（GHb）之间的关系。这种关系比乍看之下更为复杂，因为红细胞中的GHb浓度是两个过程的结果：葡萄糖与血红蛋白结合以及血液中红细胞的持续更新。衰老红细胞携带的血糖信息持续时间比年轻红细胞更长。结果是，在GHb估计之前立即发生的高血糖对GHb浓度的影响比之前发生的高血糖更大。由于在某个GHb值背后可能隐藏着不同的高血糖期，仅根据GHb浓度无法评估糖尿病患者的血糖控制情况。只有在使用综合考虑血糖、糖化血浆蛋白和糖化血红蛋白值的标准时才能进行评估。
