Virtue Mark A, Furne Julie K, Nuttall Frank Q, Levitt Michael D
Minneapolis Veterans Administration Medical Center, Minneapolis, Minnesota 55417, USA.
Diabetes Care. 2004 Apr;27(4):931-5. doi: 10.2337/diacare.27.4.931.
Subjects with decreased erythrocyte survival have an unusually low GHb percentage. The goal of this study was to determine whether hyperglycemia, as reflected by GHb percentage, is associated with decreased erythrocyte survival.
Erythrocyte survival was quantitated in 23 subjects with type 2 diabetes, and these values were correlated with the subjects' GHb percentage. Erythrocyte survival was determined from the difference between the subjects' alveolar carbon monoxide (CO) concentration and atmospheric CO concentration. Reticulocyte counts were obtained in 16 subjects.
Although the vast majority of the subjects had erythrocyte life spans that fell within the normal range (123 +/- 23 days), there was a highly significant inverse correlation (r = -0.66, P < 0.01) between life span and GHb percentage, with an average decline in life span of 6.9 days for each 1% rise in GHb. The reticulocyte count inversely correlated with erythrocyte life span (r = -0.77, P < 0.01).
Hyperglycemia, as evidenced by high GHb percentage, is associated with an appreciable decrease in erythrocyte life span. Because GHb appears to be formed over the lifetime of the erythrocyte, this decreased erythrocyte survival suggests that high GHb percentages may systematically underestimate the true degree of hyperglycemia.
红细胞存活期缩短的受试者糖化血红蛋白（GHb）百分比异常低。本研究的目的是确定以GHb百分比反映的高血糖是否与红细胞存活期缩短有关。
对23名2型糖尿病患者的红细胞存活期进行定量，并将这些值与受试者的GHb百分比进行关联分析。根据受试者肺泡一氧化碳（CO）浓度与大气CO浓度之间的差异来确定红细胞存活期。对16名受试者进行了网织红细胞计数。
尽管绝大多数受试者的红细胞寿命在正常范围内（123±23天），但寿命与GHb百分比之间存在高度显著的负相关（r = -0.66，P < 0.01），GHb每升高1%，寿命平均下降6.9天。网织红细胞计数与红细胞寿命呈负相关（r = -0.77，P < 0.01）。
高GHb百分比所证明的高血糖与红细胞寿命的显著降低有关。由于GHb似乎是在红细胞的整个生命周期中形成的，红细胞存活期的缩短表明高GHb百分比可能会系统性地低估高血糖的真实程度。
