小鼠淋巴细胞中的毒蕈碱型胆碱能受体：直接结合法的证明
Muscarinic cholinergic receptors in murine lymphocytes: demonstration by direct binding.
作者信息
Gordon M A, Cohen J J, Wilson I B
出版信息
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2902-4. doi: 10.1073/pnas.75.6.2902.
Abstract
Using [3H]quinuclidinyl benzilate as a specific cholinergic muscarinic ligand, it has been demonstrated that lymphocytes have muscarinic binding sites. There are approximately 200 sites per cell and the dissociation constant for quinuclidinyl benzilate is approximately 1 X 10(-9) M. Quinuclidinyl benzilate receptor binding is blocked by atropine and oxotremorine.
摘要
使用[3H]东莨菪碱作为一种特异性胆碱能毒蕈碱配体，已证明淋巴细胞具有毒蕈碱结合位点。每个细胞大约有200个位点，东莨菪碱的解离常数约为1×10（-9）M。东莨菪碱受体结合被阿托品和氧化震颤素阻断。
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