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1,25-Dihydroxyvitamin D3, but not retinoic acid, induces the differentiation of U937 cells.1,25-二羟基维生素D3可诱导U937细胞分化，但视黄酸则不能。
Clin Exp Immunol. 1989 May;76(2):274-7.
2
Synergistic effect of 1,25-dihydroxyvitamin D3 and retinoic acid in inducing U937 cell differentiation.1,25-二羟基维生素D3与视黄酸在诱导U937细胞分化中的协同作用。
J Nutr Sci Vitaminol (Tokyo). 1992 Oct;38(5):415-26. doi: 10.3177/jnsv.38.415.
3
Alternative differentiation of human promyelocytic leukemia cells (HL-60) induced selectively by retinoic acid and 1 alpha,25-dihydroxyvitamin D3.维甲酸和1α,25 - 二羟基维生素D3选择性诱导人早幼粒细胞白血病细胞（HL - 60）的分化
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All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-dihydroxyvitamin D3 in normal human keratinocytes.全反式维甲酸可阻断1,25 - 二羟基维生素D3对正常人角质形成细胞的抗增殖促分化作用。
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1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor.1α,25-二羟维生素D3诱导人单核细胞系U937成熟，并与人T淋巴细胞来源的一种因子协同作用，增强单核因子即单核细胞因子的产生。
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Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells.1α,25-二羟基维生素D3对原代免疫细胞中人cathelicidin抗菌肽基因的调控
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5
Effect of retinoic acid and vitamin D on the expression of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 in the human monocytic cell line U937.维甲酸和维生素D对人单核细胞系U937中白细胞介素-1β、肿瘤坏死因子-α及白细胞介素-6表达的影响
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6
Regulation of interleukin-1 and tumour necrosis factor gene expression in myelomonocytic cell lines by 1,25-dihydroxyvitamin D3.1,25 - 二羟维生素D3对骨髓单核细胞系中白细胞介素 - 1和肿瘤坏死因子基因表达的调控
Immunology. 1991 Jan;72(1):61-4.

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1 alpha,25-Dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells.1α,25-二羟基维生素D3诱导人髓系白血病细胞分化。
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Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.1α,25-二羟基维生素D3诱导小鼠髓系白血病细胞分化
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Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.维甲酸诱导人早幼粒细胞白血病细胞系（HL-60）分化
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Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis.结节病中培养的肺泡巨噬细胞对25-羟基维生素D3的代谢
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5
1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor.1α,25-二羟维生素D3诱导人单核细胞系U937成熟，并与人T淋巴细胞来源的一种因子协同作用，增强单核因子即单核细胞因子的产生。
J Clin Invest. 1984 Mar;73(3):731-9. doi: 10.1172/JCI111266.
6
Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.1,25 - 二羟维生素D3诱导单核细胞分化和骨吸收
Proc Natl Acad Sci U S A. 1983 Oct;80(19):5907-11. doi: 10.1073/pnas.80.19.5907.
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Vitamin D conversion by sarcoid lymph node homogenate.
Ann Intern Med. 1984 Jan;100(1):59-61. doi: 10.7326/0003-4819-100-1-59.
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1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone.1,25-二羟基维生素D3：一种新型免疫调节激素。
Science. 1984 Jun 29;224(4656):1438-40. doi: 10.1126/science.6427926.
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Modulation of class I HLA antigens on HL-60 promyelocytic leukemia cells by serum-free medium: re-induction by gamma-IFN and 1,25-dihydroxyvitamin D3 (calcitriol).无血清培养基对HL-60早幼粒细胞白血病细胞上I类HLA抗原的调节作用：γ-干扰素和1,25-二羟基维生素D3（骨化三醇）的再诱导作用
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10
Monoclonal antibodies specific for human monocytes, granulocytes and endothelium.对人类单核细胞、粒细胞和内皮细胞具有特异性的单克隆抗体。
Immunology. 1984 Dec;53(4):753-67.

1,25-二羟基维生素D3可诱导U937细胞分化，但视黄酸则不能。

1,25-Dihydroxyvitamin D3, but not retinoic acid, induces the differentiation of U937 cells.

作者信息

Bhalla A K, Williams M M, Lal S, Lydyard P M

机构信息

Department of Immunology, University College and Middlesex School of Medicine, London, UK.

出版信息

Clin Exp Immunol. 1989 May;76(2):274-7.

PMID:2758696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541828/
Abstract

We have examined the effects of vitamin D3 metabolites and retinoic acid on the myelomonocyte cell line U937. Inhibition of proliferation, measured by incorporation of 125iodo-deoxyuridine was seen at 72 h with 1,25-(OH)2D3 but not 25(OH)D3 or 24, 25(OH)2D3 metabolites. CD14 molecules, not normally present on U937 cells, were induced on the cell surface. However, Class II major histocompatibility complex (MHC) molecules were not induced and Class I MHC molecules not increased in density as determined by flow cytometry. Retinoic acid inhibited proliferation but failed to induce CD14 molecules. These data suggest that both 1,25(OH)2D3 and retinoic acid act as an antiproliferation signal to U937 cells; only 1,25-(OH)2D3 induces the differentiation towards a more mature phenotype.

摘要

我们研究了维生素D3代谢产物和视黄酸对髓单核细胞系U937的影响。用125碘脱氧尿苷掺入法测定增殖抑制情况，结果显示在72小时时，1,25-(OH)2D3可抑制增殖，而25(OH)D3或24,25(OH)2D3代谢产物则无此作用。U937细胞表面原本不存在的CD14分子被诱导表达。然而，通过流式细胞术测定发现，II类主要组织相容性复合体（MHC）分子未被诱导，I类MHC分子的密度也未增加。视黄酸抑制增殖，但未能诱导CD14分子表达。这些数据表明，1,25(OH)2D3和视黄酸均作为U937细胞的抗增殖信号；只有1,25-(OH)2D3能诱导其向更成熟的表型分化。