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透析前肾脏门诊就诊情况及腹膜透析患者的预后

Pre-dialysis renal clinic visits and patients' outcomes on peritoneal dialysis.

作者信息

Tang Wen, Hu Xiu-Hong, Zhu Lei, Niu Zhe-Li, Su Chu-Yan, Han Qing-Feng, Wang Tao

机构信息

Division of Nephrology, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, China.

School of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang, China.

出版信息

Int Urol Nephrol. 2016 Nov;48(11):1911-1917. doi: 10.1007/s11255-016-1400-2. Epub 2016 Sep 1.

Abstract

PURPOSE

To investigate the effect of pre-dialysis renal care on peritoneal dialysis (PD) patients' outcomes in China.

METHODS

In this retrospective cohort study, patients who started PD during January 1, 2006, to December 31, 2014, were included. Patients' medical charts were reviewed to extract the information. To explore the effect of pre-dialysis renal care on patients' outcomes, patient were divided into two groups according to whether or not they had frequent renal clinic visits: Group A (with frequent visits) and Group B (without frequent visits).

RESULTS

A total of 668 patients were included. Patients who admitted to emergency room before PD initiations were significantly higher in Group B than in Group A (42.7 vs. 33 %, p = 0.01). However, there was no significant difference in the proportion of patients requiring emergency hemodialysis prior to PD commencement (20.5 vs. 24.6 %, p = 0.21), acute heart failure (30.2 vs. 35.4 %, p = 0.16) and pulmonary infection (15.4 vs. 12.1 %, p = 0.23) between groups. Both the mortality and technical failure rate in Group A were significantly lower as compared to Group B (p = 0.003 and p < 0.01, respectively). Multivariable Cox regression analysis showed frequent pre-dialysis renal clinic visits were associated with both lower mortality rate (HR 0.62, 95 % CI 0.46-0.85, p = 0.003) and technical failure on PD (HR 0.58, 95 % CI 0.36-0.92, p = 0.022).

CONCLUSION

Pre-dialysis frequent clinic visits were associated with better PD outcomes. Pre-dialysis renal clinic management was suboptimal in the present cohort. More organized system to ensure people with established chronic kidney disease are well managed is necessary in China.

摘要

目的

探讨透析前肾脏护理对中国腹膜透析(PD)患者预后的影响。

方法

在这项回顾性队列研究中,纳入了2006年1月1日至2014年12月31日期间开始进行腹膜透析的患者。查阅患者的病历以提取信息。为了探究透析前肾脏护理对患者预后的影响,根据患者是否频繁就诊于肾脏门诊,将患者分为两组:A组(频繁就诊)和B组(非频繁就诊)。

结果

共纳入668例患者。B组患者在开始腹膜透析前入住急诊室的比例显著高于A组(42.7%对33%,p = 0.01)。然而,两组之间在开始腹膜透析前需要紧急血液透析的患者比例(20.5%对24.6%,p = 0.21)、急性心力衰竭(30.2%对35.4%,p = 0.16)和肺部感染(15.4%对12.1%,p = 0.23)方面没有显著差异。与B组相比,A组的死亡率和技术失败率均显著更低(分别为p = 0.003和p < 0.01)。多变量Cox回归分析显示,透析前频繁就诊于肾脏门诊与较低的死亡率(风险比0.62,95%置信区间0.46 - 0.85,p = 0.003)和腹膜透析技术失败均相关(风险比0.58,95%置信区间0.36 - 0.92,p = 0.022)。

结论

透析前频繁就诊与更好的腹膜透析预后相关。在本队列中,透析前肾脏门诊管理欠佳。中国有必要建立更有组织的系统,以确保慢性肾脏病患者得到良好管理。

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